Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
Int J Dermatol. 2021 Nov;60(11):e459-e465. doi: 10.1111/ijd.15677. Epub 2021 Jun 2.
Squamous cell carcinoma (SCC) can present as a rare complication of longstanding hidradenitis suppurativa (HS) lesions. Limited data exist on characteristics and outcomes of SCC development within HS lesions. The purpose of this review is to conduct a literature review of previously reported cases of SCC development in pre-existing HS lesions. EMBASE and MEDLINE searches were conducted in OVID on June 25, 2020, to yield 59 studies. Of the 95 patients (mean age: 52.9 years) who developed a total of 122 SCCs within HS lesions, the majority were males (77.9%, n = 74/95). The most common sites of SCC were the gluteal region (47.5%, n = 58/122), the perianal region (18.9%, n = 23/122), and the genitals (13.9%, n = 17/122). The mean duration between HS onset and SCC development was 25.5 years. Of the patients that had outcomes reported, 54.0% (n = 34/63) experienced SCC metastasis, 43.1% (n = 28/65) experienced SCC recurrences, and 58.7% (n = 44/75) experienced a mortality outcome. The most common documented reasons for death included metastasis (34.1%, n = 15/44) and sepsis (13.6%, n = 6/44). Patients with longstanding HS lesions can develop SCCs with a high rate of metastasis and mortality. Thus, chronic HS lesions, especially in the gluteal, perianal, genital, and perineal regions, should be monitored regularly for timely SCC diagnosis and management.
鳞状细胞癌（SCC）可作为长期化脓性汗腺炎（HS）病变的罕见并发症出现。关于 HS 病变中 SCC 发展的特征和结局的数据有限。本综述的目的是对先前报道的 HS 病变中 SCC 发展的病例进行文献回顾。2020 年 6 月 25 日，在 OVID 的 EMBASE 和 MEDLINE 上进行了检索，共获得 59 项研究。在 95 例（平均年龄：52.9 岁）共发生 122 例 SCC 的患者中，大多数为男性（77.9%，n=74/95）。SCC 最常见的部位为臀部（47.5%，n=58/122）、肛周（18.9%，n=23/122）和生殖器（13.9%，n=17/122）。从 HS 发病到 SCC 发病的平均时间为 25.5 年。有结局报道的患者中，54.0%（n=34/63）发生 SCC 转移，43.1%（n=28/65）发生 SCC 复发，58.7%（n=44/75）发生死亡。死亡最常见的原因包括转移（34.1%，n=15/44）和脓毒症（13.6%，n=6/44）。患有长期 HS 病变的患者可能会发生 SCC，其转移和死亡率较高。因此，对于慢性 HS 病变，尤其是臀部、肛周、生殖器和会阴区域的病变，应定期进行 SCC 诊断和管理，以确保及时发现病变。
