Organometallic Synthesis and Catalysis Lab, Chemical Engineering Division, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune, 411 008, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Chem Rec. 2021 Dec;21(12):3573-3588. doi: 10.1002/tcr.202100113. Epub 2021 Jun 1.
Direct C-H functionalization of privileged and biologically relevant azoles and indoles represents an important chemical transformation in molecular science. Despite significant progress in the palladium-catalyzed regioselective C-H functionalization of azoles and indoles, the use of abundant and less expensive nickel catalyst is underdeveloped. In the recent past, the nickel-catalyzed regioselective C-H alkylation, arylation, alkenylation and alkynylation of azoles and indoles have been substantially explored, which can be applied to the complex organic molecule synthesis. In this Account, we summarize the developments in nickel-catalyzed regioselective functionalization of azoles and indoles with a considerable focus on the reaction mechanism.
直接 C-H 功能化特权和生物相关的唑类和吲哚类代表了分子科学中的一个重要化学转化。尽管在钯催化的唑类和吲哚类区域选择性 C-H 功能化方面取得了重大进展，但丰富且廉价的镍催化剂的应用仍不发达。在最近的过去，已经对镍催化的唑类和吲哚类的区域选择性 C-H 烷基化、芳基化、烯基化和炔基化进行了大量的探索，这些方法可应用于复杂有机分子的合成。在本综述中，我们总结了镍催化的唑类和吲哚类区域选择性功能化的发展，重点讨论了反应机理。
