McCawley M, Lippmann M
Institute of Environmental Medicine, New York University Medical Center, NY 10016.
Am Ind Hyg Assoc J. 1988 Jul;49(7):357-66. doi: 10.1080/15298668891379891.
The dispersion of a 0.5 micron aerosol bolus during tidal breathing differs significantly (p less than 0.0001) between a group of smokers (with approximately 20 pack-years average exposure) and a comparable group of nonsmokers. Their mean differences in standard respiratory function indexes from spirometry [forced vital capacity (FVC), forced expiratory volume in one second (FEV1), mean forced expiratory flow during the middle half of the FVC (FEF25-75)] were smaller and not statistically significant. The test is simple to perform and may be done as quickly as spirometry but without using a forced exhalation. Comparison of the coefficients of variation for the dispersion test and FEV1 indicate that the aerosol dispersion test may be useful in epidemiologic investigations either by reducing the required population size or increasing the level of confidence.
在潮式呼吸过程中，一组吸烟者（平均暴露量约为20包年）和一组可比的非吸烟者之间，0.5微米气溶胶团块的扩散存在显著差异（p小于0.0001）。他们在肺量计标准呼吸功能指标[用力肺活量（FVC）、一秒用力呼气量（FEV1）、FVC中间一半时间的平均用力呼气流量（FEF25-75）]上的平均差异较小且无统计学意义。该测试操作简单，可与肺量计测试一样快速完成，但无需用力呼气。扩散测试和FEV1变异系数的比较表明，气溶胶扩散测试通过减少所需的人群规模或提高置信水平，可能在流行病学调查中有用。
