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鉴定人宫颈癌 HeLa 细胞中化疗和放疗耐药的干细胞亚群。

Identification of Chemo and Radio-Resistant Sub-Population of Stem Cells in Human Cervical Cancer HeLa Cells.

机构信息

Department of Biochemistry, Faculty of Pharmacy, Kafrelsheikh University, Egypt.

Department of Biochemistry, Faculty of Pharmacy, Minia University, Egypt.

出版信息

Cancer Invest. 2021 Sep;39(8):661-674. doi: 10.1080/07357907.2021.1931875. Epub 2021 Jul 8.

DOI:10.1080/07357907.2021.1931875
PMID:34076552
Abstract

BACKGROUND

Cervical cancer ranks the second female malignancy after breast cancer. Cancer stem cells (CSCs) are hard to be eradicated, so can recur. We aim to isolate and characterize CSCs from HeLa cells.

METHODS

These cells express clusters of differentiation (CDs), 44 and 24, to be sorted by fluorescence-activated cell sorting (FACS).

RESULTS

CD44CD24 cells showed potential to form spheres, tumorigenicity, stemness genes and higher resistance to cisplatin, X-ray.

CONCLUSION

CD44CD24 HeLa cells hold characteristics of CSCs, , studies, suggesting that targeting may lead to screening of new anti-cancer therapies.

摘要

背景

宫颈癌是女性第二大恶性肿瘤，仅次于乳腺癌。癌症干细胞（CSC）难以根除，因此容易复发。本研究旨在从 HeLa 细胞中分离和鉴定 CSC。

方法

这些细胞表达簇分化（CD）44 和 CD24，可通过荧光激活细胞分选（FACS）进行分选。

结果

CD44CD24 细胞具有形成球体、致瘤性、干性基因和更高的顺铂、X 射线耐药性的潜能。

结论

CD44CD24 HeLa 细胞具有 CSC 的特征，这为进一步研究提供了依据，提示靶向治疗可能为筛选新的抗癌疗法提供线索。

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