Zhang Hanqun, Wang Xiaohu, Ma Yan, Zhang Qiuning, Liu Ruifeng, Luo Hongtao, Wang Zi
The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
Department of Oncology, Guizhou Provincial People's Hospital, Guizhou, China.
Front Oncol. 2023 Aug 22;13:1164985. doi: 10.3389/fonc.2023.1164985. eCollection 2023.
Radiotherapy is one of the main treatments for cervical cancer. Early cervical cancer is usually considered postoperative radiotherapy alone. Radiotherapy combined with cisplatin is the standard treatment for locally advanced cervical cancer (LACC), but sometimes the disease will relapse within a short time after the end of treatment. Tumor recurrence is usually related to the inherent radiation resistance of the tumor, mainly involving cell proliferation, apoptosis, DNA repair, tumor microenvironment, tumor metabolism, and stem cells. In the past few decades, the mechanism of radiotherapy resistance of cervical cancer has been extensively studied, but due to its complex process, the specific mechanism of radiotherapy resistance of cervical cancer is still not fully understood. In this review, we discuss the current status of radiotherapy resistance in cervical cancer and the possible mechanisms of radiotherapy resistance, and provide favorable therapeutic targets for improving radiotherapy sensitivity. In conclusion, this article describes the importance of understanding the pathway and target of radioresistance for cervical cancer to promote the development of effective radiotherapy sensitizers.
放射治疗是宫颈癌的主要治疗方法之一。早期宫颈癌通常仅考虑术后放疗。放疗联合顺铂是局部晚期宫颈癌（LACC）的标准治疗方法，但有时疾病会在治疗结束后短时间内复发。肿瘤复发通常与肿瘤固有的放射抗性有关，主要涉及细胞增殖、凋亡、DNA修复、肿瘤微环境、肿瘤代谢和干细胞。在过去几十年中，宫颈癌放射抗性的机制已得到广泛研究，但由于其过程复杂，宫颈癌放射抗性的具体机制仍未完全了解。在本综述中，我们讨论了宫颈癌放射抗性的现状和可能的放射抗性机制，并为提高放疗敏感性提供了有利的治疗靶点。总之，本文描述了了解宫颈癌放射抗性途径和靶点对于促进有效放疗增敏剂发展的重要性。
