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益生菌对预防大鼠肠道黏膜辐射诱导形态学变化的作用。

The effect of probiotics for preventing radiation-induced morphological changes in intestinal mucosa of rats.

作者信息

Ki Yongkan, Kim Wontaek, Cho Heunglae, Ahn Kijung, Choi Youngmin, Kim Dongwon

机构信息

Department of Radiation Oncology, Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.

Department of Radiation Oncology, Inje University College of Medicine, Busan, Korea.

出版信息

J Korean Med Sci. 2014 Oct;29(10):1372-8. doi: 10.3346/jkms.2014.29.10.1372. Epub 2014 Oct 8.

DOI:10.3346/jkms.2014.29.10.1372
PMID:25368490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4214937/
Abstract

Radiation therapy is an important treatment modality for abdominal or pelvic cancer, but there is a common and serious complication such as radiation-induced enteritis. Probiotics is reported to have positive effects against radiation-induced enteropathy. In this study, morphological changes of bowel mucosa were analyzed in rats to presume the effect of probiotics on radiation-induced enteritis and its correlation with radiation dose. A total of 48 adult male Sprague-Dawley rats were randomly assigned to two groups and received a solution containing 1.0×10(8) colony-forming units of Lactiobacillus acidophilus or water once daily for 10 days. Each of two groups was divided into three subgroups and abdomino-pelvic area of each subgroup was irradiated with 10, 15, and 20 Gy, respectively on the seventh day of feeding the solutions. All rats were sacrificed 3 days after irradiation and the mucosal thickness and villus height of jejunum, ileum and colon were measured. The morphological parameters of the small intestine represented significant differences between two solution groups irradiated 10 or 15 Gy, except for villus height of jejunum in 15 Gy-subgroup (P=0.065). There was no significant morphometric difference between two groups irradiated with 20 Gy of radiation. Probiotics appear to be effective for the morphological shortening of small intestinal mucosa damaged by radiation less than or equal to 15 Gy.

摘要

放射治疗是腹部或盆腔癌症的一种重要治疗方式，但存在诸如放射性肠炎等常见且严重的并发症。据报道，益生菌对放射性肠病有积极作用。在本研究中，分析大鼠肠黏膜的形态变化，以推测益生菌对放射性肠炎的影响及其与辐射剂量的相关性。总共48只成年雄性Sprague-Dawley大鼠被随机分为两组，每天接受一次含有1.0×10(8) 嗜酸乳杆菌菌落形成单位的溶液或水，持续10天。两组中的每组又分为三个亚组，在喂食溶液的第七天，分别对每个亚组的腹盆腔区域给予10、15和20 Gy的辐射。所有大鼠在照射后3天处死，测量空肠、回肠和结肠的黏膜厚度和绒毛高度。小肠的形态学参数在接受10或15 Gy辐射的两个溶液组之间存在显著差异，但15 Gy亚组的空肠绒毛高度除外（P = 0.065）。接受20 Gy辐射的两组之间在形态测量上没有显著差异。益生菌似乎对小于或等于15 Gy辐射损伤的小肠黏膜形态缩短有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6438/4214937/3ceb12fe21f0/jkms-29-1372-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6438/4214937/ed860a3f387d/jkms-29-1372-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6438/4214937/42062d95078f/jkms-29-1372-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6438/4214937/aa17f39db446/jkms-29-1372-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6438/4214937/41e273952392/jkms-29-1372-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6438/4214937/826a11f4c6fe/jkms-29-1372-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6438/4214937/3ceb12fe21f0/jkms-29-1372-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6438/4214937/ed860a3f387d/jkms-29-1372-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6438/4214937/42062d95078f/jkms-29-1372-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6438/4214937/aa17f39db446/jkms-29-1372-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6438/4214937/41e273952392/jkms-29-1372-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6438/4214937/826a11f4c6fe/jkms-29-1372-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6438/4214937/3ceb12fe21f0/jkms-29-1372-g006.jpg

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