Futaki T, Semba T, Kudo Y
Department of Otolaryngology, University of Tokyo, Japan.
Am J Otol. 1988 Mar;9(2):131-5.
Recently several investigations have been reported suggesting that the cause of endolymphatic hydrops might be an immunologic disorder of the endolymphatic space, including the endolymphatic sac. As the first choice in a conservative treatment by medication, the authors have used a combination of prednisolone and furosemide per os, which is rather safe and effective for hydrops patients in a subacute stage. However, some patients do not respond to this treatment or gradually become immune to this medication. With these patients, we have tried an intravenous administration of immunoglobulin G with methyl B12, expecting a curative effect on immunologic deficiency in the endolymphatic space. Compared with a group of patients without this treatment, the group receiving it showed rather good scores in hearing improvement; however, vertigo and tinnitus remained almost unchanged.
最近有几项研究报告表明，内淋巴积水的病因可能是内淋巴间隙（包括内淋巴囊）的免疫紊乱。作为药物保守治疗的首选，作者采用了口服泼尼松龙和呋塞米的联合用药，这对亚急性期的积水患者相当安全有效。然而，一些患者对这种治疗没有反应，或者逐渐对这种药物产生免疫。对于这些患者，我们尝试静脉注射免疫球蛋白G和甲钴胺，期望对内淋巴间隙的免疫缺陷有治疗效果。与未接受这种治疗的一组患者相比，接受治疗的组在听力改善方面得分相当不错；然而，眩晕和耳鸣几乎没有变化。
