对老年人循环瘦素和脂联素水平的海洋 ω-3 脂肪酸影响进行二次数据分析。
Secondary data analysis investigating effects of marine omega-3 fatty acids on circulating levels of leptin and adiponectin in older adults.
机构信息
The Ohio State University, College of Nursing, 1585 Neil Avenue, Columbus, Ohio 43210.
The Ohio State University, College of Nursing, 1585 Neil Avenue, Columbus, Ohio 43210.
出版信息
Prostaglandins Leukot Essent Fatty Acids. 2021 Jul;170:102302. doi: 10.1016/j.plefa.2021.102302. Epub 2021 May 24.
BACKGROUND
Higher leptin and lower adiponectin levels have been linked to progressing systemic inflammation and diseases of aging. Among older adults with obesity and an inflammatory conditions, we quantified effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation on leptin, adiponectin, and the leptin-to-adiponectin ratio (LAR). We also examined associations among adipokine and cytokine levels.
METHODS
Using a randomized, double-blind, placebo-controlled design, participants (mean age 61.3 ± 2.1) received 1.5 g EPA + 1.0 g DHA (n = 14) or mineral oil (n = 18) daily. Plasma adipokine and cytokine levels were quantified by electrochemiluminescence at all study intervals.
RESULTS
While no between-group differences were detected, there was a reduction in the LAR (by 23%, p=.065) between weeks 4 and 8 among the EPA+DHA group. Adiponectin levels were negatively associated with IL-1β levels at week 4 (p=.02) and TNF-α levels at week 8 (p=.03).
CONCLUSION
Potential benefits of EPA+DHA supplementation among aging populations warrant further study.
背景
较高的瘦素和较低的脂联素水平与进行性全身炎症和衰老相关疾病有关。在肥胖且存在炎症的老年人中，我们定量评估了二十碳五烯酸 (EPA) 和二十二碳六烯酸 (DHA) 补充对瘦素、脂联素和瘦素与脂联素比值 (LAR) 的影响。我们还研究了脂肪因子和细胞因子水平之间的关联。
方法
采用随机、双盲、安慰剂对照设计，参与者（平均年龄 61.3 ± 2.1 岁）每天接受 1.5 g EPA + 1.0 g DHA（n = 14）或矿物油（n = 18）。在所有研究间隔期间，通过电化学发光法定量测定血浆脂肪因子和细胞因子水平。
结果
尽管组间无差异，但在 EPA+DHA 组中，第 4 周到第 8 周 LAR 降低了 23%（p =.065）。脂联素水平与第 4 周的 IL-1β 水平（p =.02）和第 8 周的 TNF-α 水平（p =.03）呈负相关。
结论
EPA+DHA 补充对老年人群体的潜在益处值得进一步研究。
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