Li Yimeng, Zhong Lishi, Zhang Lili, Shen Xiaobing, Kong Lu, Wu Tianshu
Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, People's Republic of China.
Environ Toxicol Chem. 2021 Sep;40(9):2406-2424. doi: 10.1002/etc.5133. Epub 2021 Jul 22.
Along with the rapid development of nanotechnology, the biosafety assessment of nanotechnology products, including nanomaterials (NMs), has become more and more important. The nematode Caenorhabditis elegans is a valuable model organism that has been widely used in the field of biology because of its excellent advantages, including low cost, small size, short life span, and highly conservative genomes with vertebral animals. In recent years, the number of nanotoxicological researchers using C. elegans has been growing. According to these available studies, the present review classified the adverse effects of NMs in C. elegans into systematic, cellular, and molecular toxicity, and focused on summarizing and analyzing the underlying mechanisms of metal, metal oxide, and nonmetallic NMs causing toxic effects in C. elegans. Our findings provide insights into what further studies are needed to assess the biosafety of NMs in the ecosystem using C. elegans. Environ Toxicol Chem 2021;40:2406-2424. © 2021 SETAC.
随着纳米技术的迅速发展，包括纳米材料（NMs）在内的纳米技术产品的生物安全性评估变得越来越重要。线虫秀丽隐杆线虫是一种有价值的模式生物，因其具有成本低、体型小、寿命短以及基因组与脊椎动物高度保守等优异优势，已在生物学领域得到广泛应用。近年来，使用秀丽隐杆线虫进行纳米毒理学研究的人员数量一直在增加。根据这些现有研究，本综述将纳米材料对秀丽隐杆线虫的不利影响分为系统毒性、细胞毒性和分子毒性，并着重总结和分析了金属、金属氧化物和非金属纳米材料在秀丽隐杆线虫中产生毒性作用的潜在机制。我们的研究结果为进一步开展研究以评估纳米材料在生态系统中使用秀丽隐杆线虫时的生物安全性提供了见解。《环境毒理学与化学》2021年；40:2406 - 2424。© 2021 SETAC。
