Villani Stefania, Calcagnile Matteo, Demitri Christian, Alifano Pietro
Department of Engineering for Innovation, University of Salento, Via Monteroni, 73100 Lecce, Italy.
Department of Experimental Medicine, University of Salento, Via Monteroni, 73100 Lecce, Italy.
Nanomaterials (Basel). 2025 Jan 3;15(1):67. doi: 10.3390/nano15010067.
The spread of multidrug-resistant microbes has made it necessary and urgent to develop new strategies to deal with the infections they cause. Some of these are based on nanotechnology, which has revolutionized many fields in medicine. Evaluating the safety and efficacy of these new antimicrobial strategies requires testing in animal models before being tested in clinical trials. In this context, could represent a valid alternative to traditional mammalian and non-mammalian animal models, due to its low cost, ease of handling, and valuable biological properties to investigate host-pathogen interactions. The purpose of this review is to provide an updated overview of the literature concerning the use of larvae as an animal model to evaluate safety and efficacy of nanoparticles and nanomaterials, particularly, of those that are used or are under investigation to combat microbial pathogens.
多重耐药微生物的传播使得开发应对它们所引起感染的新策略变得必要且紧迫。其中一些策略基于纳米技术，纳米技术已经彻底改变了医学的许多领域。在进行临床试验之前，评估这些新的抗菌策略的安全性和有效性需要在动物模型中进行测试。在这种情况下，由于其成本低、易于操作以及在研究宿主 - 病原体相互作用方面具有重要的生物学特性， 可能是传统哺乳动物和非哺乳动物动物模型的有效替代方案。本综述的目的是提供有关使用 幼虫作为动物模型来评估纳米颗粒和纳米材料安全性和有效性的文献的最新概述，特别是那些用于或正在研究以对抗微生物病原体的纳米颗粒和纳米材料。
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