• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

LSD1 缺失的肌成纤维细胞可减轻 TAC 诱导的心力衰竭。

Myofibroblast Deficiency of LSD1 Alleviates TAC-Induced Heart Failure.

机构信息

State Key Laboratory of Esophageal Cancer Prevention and Treatment, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education of China; School of Pharmaceutical Sciences, Zhengzhou University (J.-L.H., L.J., Q.A., X.C., Y.Q., B.W., Y.Z., X.S., H.-M.L., C.W., W.Z.).

Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA (E.G.).

出版信息

Circ Res. 2021 Jul 23;129(3):400-413. doi: 10.1161/CIRCRESAHA.120.318149. Epub 2021 Jun 3.

DOI:10.1161/CIRCRESAHA.120.318149
PMID:34078090
Abstract

[Figure: see text].

摘要

[图:见正文]。

相似文献

1
Myofibroblast Deficiency of LSD1 Alleviates TAC-Induced Heart Failure.LSD1 缺失的肌成纤维细胞可减轻 TAC 诱导的心力衰竭。
Circ Res. 2021 Jul 23;129(3):400-413. doi: 10.1161/CIRCRESAHA.120.318149. Epub 2021 Jun 3.
2
Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation.动态染色质靶向 BRD4 可刺激心脏成纤维细胞活化。
Circ Res. 2019 Sep 13;125(7):662-677. doi: 10.1161/CIRCRESAHA.119.315125. Epub 2019 Aug 14.
3
SMAD-independent down-regulation of caveolin-1 by TGF-β: effects on proliferation and survival of myofibroblasts.转化生长因子-β对小窝蛋白-1的SMAD非依赖性下调:对肌成纤维细胞增殖和存活的影响
PLoS One. 2015 Feb 6;10(2):e0116995. doi: 10.1371/journal.pone.0116995. eCollection 2015.
4
Decorin gene delivery inhibits cardiac fibrosis in spontaneously hypertensive rats by modulation of transforming growth factor-beta/Smad and p38 mitogen-activated protein kinase signaling pathways.decorin 基因转导通过调节转化生长因子-β/smad 和 p38 丝裂原活化蛋白激酶信号通路抑制自发性高血压大鼠心肌纤维化。
Hum Gene Ther. 2009 Oct;20(10):1190-200. doi: 10.1089/hum.2008.204.
5
MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart.心肌肥厚中的丝裂原活化蛋白激酶激活的蛋白激酶 2和心脏中环氧化酶-2 的调节。
Circ Res. 2010 Apr 30;106(8):1434-43. doi: 10.1161/CIRCRESAHA.109.213199. Epub 2010 Mar 25.
6
Olmesartan ameliorates pressure overload-induced cardiac remodeling through inhibition of TAK1/p38 signaling in mice.奥美沙坦通过抑制小鼠体内的TAK1/p38信号通路改善压力超负荷诱导的心脏重塑。
Life Sci. 2016 Jan 15;145:121-6. doi: 10.1016/j.lfs.2015.12.034. Epub 2015 Dec 17.
7
Infarct Collagen Topography Regulates Fibroblast Fate via p38-Yes-Associated Protein Transcriptional Enhanced Associate Domain Signals.梗死胶原形貌通过 p38-Yes 相关蛋白转录增强相关结构域信号调节成纤维细胞命运。
Circ Res. 2020 Oct 23;127(10):1306-1322. doi: 10.1161/CIRCRESAHA.119.316162. Epub 2020 Sep 4.
8
Epoxyeicosatrienoic acid prevents maladaptive remodeling in pressure overload by targeting calcineurin/NFAT and Smad-7.环氧二十碳三烯酸通过靶向钙调神经磷酸酶/NFAT 和 Smad-7 预防压力超负荷引起的适应性重构。
Exp Cell Res. 2020 Jan 1;386(1):111716. doi: 10.1016/j.yexcr.2019.111716. Epub 2019 Nov 14.
9
TRPV1 potentiates TGFβ-induction of corneal myofibroblast development through an oxidative stress-mediated p38-SMAD2 signaling loop.TRPV1 通过氧化应激介导的 p38-SMAD2 信号通路增强 TGFβ 诱导的角膜肌成纤维细胞发育。
PLoS One. 2013 Oct 2;8(10):e77300. doi: 10.1371/journal.pone.0077300. eCollection 2013.
10
Transplantation of myoblast sheets that secrete the novel peptide SVVYGLR improves cardiac function in failing hearts.肌母细胞片移植可分泌新型肽 SVVYGLR,改善衰竭心脏的心功能。
Cardiovasc Res. 2013 Jul 1;99(1):102-10. doi: 10.1093/cvr/cvt088. Epub 2013 Apr 23.

引用本文的文献

1
Histone methylation of kidney disease: fact or fantasy?肾脏疾病中的组蛋白甲基化:事实还是幻想?
Ren Fail. 2025 Dec;47(1):2538801. doi: 10.1080/0886022X.2025.2538801. Epub 2025 Sep 10.
2
The epigenetic regulation of crosstalk between cardiac fibroblasts and other cardiac cell types during stress.应激期间心脏成纤维细胞与其他心脏细胞类型之间串扰的表观遗传调控。
Front Cardiovasc Med. 2025 Apr 8;12:1539826. doi: 10.3389/fcvm.2025.1539826. eCollection 2025.
3
Lysine Demethylase 1 Has Demethylase-Dependent and Non-Canonical Functions in Myofibroblast Activation in Systemic Sclerosis.
赖氨酸去甲基化酶1在系统性硬化症肌成纤维细胞激活中具有依赖去甲基化酶的功能和非经典功能。
Cells. 2025 Mar 14;14(6):433. doi: 10.3390/cells14060433.
4
Co-administration of isoprenaline and phenylephrine induced a new HFrEF mouse model through activation of both SNS and RAAS.异丙肾上腺素和去氧肾上腺素联合给药通过激活交感神经系统(SNS)和肾素-血管紧张素-醛固酮系统(RAAS)诱导了一种新的射血分数降低的心力衰竭(HFrEF)小鼠模型。
Front Cardiovasc Med. 2025 Mar 10;12:1531509. doi: 10.3389/fcvm.2025.1531509. eCollection 2025.
5
Direct fibroblast reprogramming: an emerging strategy for treating organic fibrosis.直接成纤维细胞重编程:一种治疗器官纤维化的新兴策略。
J Transl Med. 2025 Feb 27;23(1):240. doi: 10.1186/s12967-024-06060-3.
6
Fibroblast-derived miR-425-5p alleviates cardiac remodelling in heart failure via inhibiting the TGF-β1/Smad signalling.成纤维细胞衍生的 miR-425-5p 通过抑制 TGF-β1/Smad 信号通路缓解心力衰竭中的心脏重构。
J Cell Mol Med. 2024 Nov;28(21):e70199. doi: 10.1111/jcmm.70199.
7
Epigenetic Regulation in Myocardial Fibroblasts and Its Impact on Cardiovascular Diseases.心肌成纤维细胞中的表观遗传调控及其对心血管疾病的影响。
Pharmaceuticals (Basel). 2024 Oct 10;17(10):1353. doi: 10.3390/ph17101353.
8
Single-Cell RNA Sequencing and Combinatorial Approaches for Understanding Heart Biology and Disease.用于理解心脏生物学与疾病的单细胞RNA测序及组合方法
Biology (Basel). 2024 Sep 30;13(10):783. doi: 10.3390/biology13100783.
9
LMK235 ameliorates inflammation and fibrosis after myocardial infarction by inhibiting LSD1-related pathway.LMK235 通过抑制 LSD1 相关通路改善心肌梗死后的炎症和纤维化。
Sci Rep. 2024 Oct 8;14(1):23450. doi: 10.1038/s41598-024-74887-3.
10
ELM2-SANT Domain-Containing Scaffolding Protein 1 Regulates Differentiation and Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells.ELM2-SANT 结构域包含支架蛋白 1 调节人诱导多能干细胞来源的心肌细胞的分化和成熟。
J Am Heart Assoc. 2024 Jul 2;13(13):e034816. doi: 10.1161/JAHA.124.034816. Epub 2024 Jun 21.