Hayes Kelly S, Grencis Richard K
Lydia Becker Institute of Immunology and Inflammation, Wellcome Trust Centre for Cell Matrix Research and Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Parasitology. 2021 Jun 3;148(14):1-9. doi: 10.1017/S0031182021000883.
Trichuris muris is a mouse intestinal parasitic nematode that inhabits the large intestine of its host and induces a strong immune response. The effects of this strong anti-parasite response can be found locally within the intestinal niche and also systemically, having effects on multiple organs. Additionally, the anti-parasite response can have multiple effects on infectious organisms and on microbiota that the host is harbouring. It has been shown that Th1 responses induced by T. muris can affect progression of bowel inflammation, cause colitic-like intestinal inflammation, reduce barrier function and intestinal mucosal responses. In the brain, T. muris can exacerbate stroke outcome and other neurological conditions. In the lung, T. muris can suppress airway inflammation and alter immune responses to other parasites. Additionally, T. muris induced responses can inhibit anti-tumour immunity. Although this parasite maintains a localized niche in the large intestine, its effects can be far-reaching and substantially impact other infections through modulation of bystander immune responses.
鼠鞭虫是一种寄生于小鼠肠道的线虫，栖息于宿主的大肠内，并引发强烈的免疫反应。这种强烈的抗寄生虫反应的影响不仅局限于肠道微环境，还会波及全身，对多个器官产生作用。此外，抗寄生虫反应会对宿主携带的感染性生物和微生物群产生多种影响。研究表明，鼠鞭虫诱导的Th1反应会影响肠道炎症的进展，引发结肠炎样肠道炎症，降低屏障功能和肠道黏膜反应。在大脑中，鼠鞭虫会加重中风后果和其他神经系统疾病。在肺部，鼠鞭虫会抑制气道炎症，并改变对其他寄生虫的免疫反应。此外，鼠鞭虫诱导的反应会抑制抗肿瘤免疫。尽管这种寄生虫在大肠中维持着局部微环境，但其影响却可能十分深远，并通过调节旁观者免疫反应对其他感染产生重大影响。
