Ham Hyeon Joo, Yeo In Jun, Jeon Seong Hee, Lim Jun Hyung, Yoo Sung Sik, Son Dong Ju, Jang Sung-Su, Lee Haksup, Shin Seung-Jin, Han Sang Bae, Yun Jae Suk, Hong Jin Tae
College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 28644, Republic of Korea.
ATGC Co., Seoul 06372, Republic of Korea.
Biomol Ther (Seoul). 2022 Jan 1;30(1):90-97. doi: 10.4062/biomolther.2021.077.
Recently, increasing evidence suggests that neuroinflammation may be a critical factor in the development of Parkinson's disease (PD) in addition to the ratio of acetylcholine/dopamine because dopaminergic neurons are particularly vulnerable to inflammatory attack. In this study, we investigated whether botulinum neurotoxin A (BoNT-A) was effective for the treatment of PD through its anti-neuroinflammatory effects and the modulation of acetylcholine and dopamine release. We found that BoNT-A ameliorated MPTP and 6-OHDA-induced PD progression, reduced acetylcholine release, levels of IL-1β, IL-6 and TNF-α as well as GFAP expression, but enhanced dopamine release and tyrosine hydroxylase expression. These results indicated that BoNT-A had beneficial effects on MPTP or 6-OHDA-induced PD-like behavior impairments via its anti-neuroinflammation properties, recovering dopamine, and reducing acetylcholine release.
最近，越来越多的证据表明，除了乙酰胆碱/多巴胺的比例外，神经炎症可能是帕金森病（PD）发展的一个关键因素，因为多巴胺能神经元特别容易受到炎症攻击。在本研究中，我们调查了肉毒杆菌神经毒素A（BoNT-A）是否通过其抗神经炎症作用以及对乙酰胆碱和多巴胺释放的调节来有效治疗PD。我们发现，BoNT-A改善了MPTP和6-OHDA诱导的PD进展，减少了乙酰胆碱释放、IL-1β、IL-6和TNF-α水平以及GFAP表达，但增加了多巴胺释放和酪氨酸羟化酶表达。这些结果表明，BoNT-A通过其抗神经炎症特性、恢复多巴胺和减少乙酰胆碱释放，对MPTP或6-OHDA诱导的PD样行为损伤具有有益作用。
