Neurology Department, Perugia General Hospital and University Hospital of Perugia, 06156 Perugia, Italy.
Movement Disorders Center, Neurology Department, Perugia General Hospital and University Hospital of Perugia, 06156 Perugia, Italy.
Toxins (Basel). 2024 Nov 3;16(11):474. doi: 10.3390/toxins16110474.
Freezing of gait is a frequent phenomenon and can be one of the most debilitating motor impairments in Parkinson's disease, especially in the advanced stages. It is currently defined as a brief episodic absence or any marked reduction in the forward progression of the feet, despite the intention to walk. Greater severity of freezing of gait has been associated with more frequent falls, postural instability, and executive dysfunction. However, botulinum neurotoxin is one of the most widely administered therapies for motor and non-motor symptoms, including freezing of gait, in parkinsonism. To date, the literature has had conflicting results on the use of botulinum toxin in the treatment of freezing of gait in Parkinson's disease patients. In light of this, we reviewed the findings of past studies that specifically investigated the effects of botulinum toxin on freezing of gait in Parkinson's disease in order to better understand this issue.
冻结步态是一种常见的现象，也是帕金森病患者中最具致残性的运动障碍之一，尤其是在疾病晚期。目前，冻结步态被定义为一种短暂的、突发性的脚部前进缺失或明显减缓，尽管患者有行走的意图。冻结步态越严重，跌倒、姿势不稳和执行功能障碍的发生频率就越高。然而，肉毒毒素是治疗帕金森病运动和非运动症状（包括冻结步态）最广泛应用的疗法之一。迄今为止，关于肉毒毒素治疗帕金森病患者冻结步态的文献结果存在争议。有鉴于此，我们回顾了过去专门研究肉毒毒素对帕金森病冻结步态影响的研究结果，以便更好地了解这一问题。
