Ding Li, Pang Gaofeng
Department of Pediatrics, Changzhou Children's Hospital of Nantong University, Changzhou, 213003, People's Republic of China.
Department of Pediatrics, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, People's Republic of China.
Int J Gen Med. 2021 May 27;14:2109-2115. doi: 10.2147/IJGM.S303339. eCollection 2021.
To explore the brain regions with higher functional connectivity with the cerebellum at resting state and the brain functions related to cognitive function in children with attention-deficit hyperactivity disorder (ADHD).
Thirty children with ADHD and 33 typically developing children (TDC) were examined using resting-state functional magnetic resonance imaging (fMRI) scans. Seed-based functional connectivity (FC) analysis was performed.
Four brain areas with higher FC values were identified in ADHD children. These four areas were the left middle frontal gyrus, right middle frontal gyrus, right superior temporal gyrus and left parahippocampal gyrus (P < 0.05). The results of the CPT show that the number of omission errors was significantly higher in the children with ADHD than in the TD group (5.13±5.12 vs 2.18±2.36, P = 0.000). The commission number in the ADHD group was also significantly higher than that of the TD group (4.03±6.56 vs 2.00±2.85, P = 0.002). However, no statistically significant difference was observed in the correct reaction time between the two groups (641.54±146.79 ms vs 584.81±145.82 ms, P = 0.835).
The dysfunction of cerebellar functional connectivity in specific brain regions may be one of the pathological and physiological causes of cognitive impairment of ADHD.
探讨注意缺陷多动障碍（ADHD）患儿静息状态下与小脑功能连接性较高的脑区以及与认知功能相关的脑功能。
对30名ADHD患儿和33名发育正常儿童（TDC）进行静息态功能磁共振成像（fMRI）扫描检查。采用基于种子点的功能连接（FC）分析。
ADHD患儿中确定了4个功能连接值较高的脑区。这4个区域为左侧额中回、右侧额中回、右侧颞上回和左侧海马旁回（P<0.05）。连续性能测试（CPT）结果显示，ADHD患儿的遗漏错误数显著高于TD组（5.13±5.12 vs 2.18±2.36，P = 0.000）。ADHD组的错误数也显著高于TD组（4.03±6.56 vs 2.00±2.85，P = 0.002）。然而，两组间正确反应时间无统计学显著差异（641.54±146.79 ms vs 584.81±145.82 ms，P = 0.835）。
特定脑区小脑功能连接功能障碍可能是ADHD认知障碍的病理生理原因之一。
