Yano Tomonori, Ohata Atsushi, Hiraki Yuji, Tanaka Makoto, Shinozaki Satoshi, Lefor Alan Kawarai, Yamamoto Hironori
Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan.
Naruto Research Institute, Research and Development Center, Otsuka Pharmaceutical Factory, Inc., Tokushima, Japan.
Endosc Int Open. 2021 Jun;9(6):E918-E924. doi: 10.1055/a-1396-4236. Epub 2021 May 27.
Gel immersion endoscopy is a novel technique to secure the visual field during endoscopy. The aim of this study was to develop a dedicated gel for this technique. To identify appropriate viscoelasticity and electrical conductivity, various gels were examined. Based on these results, the dedicated gel "OPF-203" was developed. Efficacy and safety of OPF-203 were evaluated in a porcine model. experiments showed that a viscosity of 230 to 1900 mPa·s, loss tangent (tanδ) ≤ 0.6, and hardness of 240 to 540 N/cm were suitable. experiments showed electrical conductivity ≤ 220 μS/cm is appropriate. experiments using gastrointestinal bleeding showed that OPF-203 provided clear visualization compared to water. After electrocoagulation of gastric mucosa in OPF-203, severe coagulative necrosis was not observed in the muscularis but limited to the mucosa. OPF-203 is useful for gel immersion endoscopy.
凝胶浸没式内镜检查是一种在内镜检查过程中确保视野的新技术。本研究的目的是开发一种适用于该技术的专用凝胶。为了确定合适的粘弹性和电导率，对各种凝胶进行了检查。基于这些结果，开发了专用凝胶“OPF - 203”。在猪模型中评估了OPF - 203的有效性和安全性。实验表明，粘度为230至1900 mPa·s、损耗角正切（tanδ）≤0.6以及硬度为240至540 N/cm是合适的。实验表明电导率≤220 μS/cm是合适的。使用胃肠道出血的实验表明，与水相比，OPF - 203能提供清晰的视野。在OPF - 203中对胃黏膜进行电凝后，肌层未观察到严重的凝固性坏死，仅局限于黏膜层。OPF - 203对凝胶浸没式内镜检查很有用。
