De Voeght A, Jaspers A, Beguin Y, Baron F, De Prijck B
Service d'Hématologie, CHU Liège, Belgique.
Rev Med Liege. 2021 May;76(5-6):470-475.
Acute leukemias are a heterogeneous group of malignant hemopathies which are subdivided according to the cytological orientation of the pathological blast cell into lymphoblastic (ALL) and myeloblastic (AML) acute leukemias. Recent advances in the biological and genetic understanding of these diseases have led to improved treatments. Specific chemotherapy treatment or so-called «targeted» treatments, advances in bone marrow transplantation and better supportive care have gradually improved the prognosis. This review, focused on the adult patient, aims to describe recent progress in terms of diagnosis, prognostic markers and therapy.
急性白血病是一组异质性恶性血液病，根据病理性原始细胞的细胞学方向可细分为淋巴细胞性（ALL）和髓细胞性（AML）急性白血病。近年来，对这些疾病生物学和遗传学认识的进展带来了更好的治疗方法。特定的化疗或所谓的“靶向”治疗、骨髓移植的进展以及更好的支持治疗逐渐改善了预后。本综述聚焦于成年患者，旨在描述在诊断、预后标志物和治疗方面的最新进展。
