Zhang Wenlu, Wen Wen, Tan Ran, Zhang Meirui, Zhong Tantan, Wang Jianhong, Chen Haiping, Fang Xiaosheng
Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong First Medical University, Jinan, Shandong 250021, P.R. China.
Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, P.R. China.
Oncol Lett. 2024 Sep 30;28(6):574. doi: 10.3892/ol.2024.14707. eCollection 2024 Dec.
Ferroptosis is a relatively recently discovered type of regulated cell death that is induced by iron-dependent lipid peroxidation. The key contributing factors to ferroptosis are the loss of glutathione peroxidase 4 which is required for reversing lipid peroxidation, the buildup of redox-active iron and the oxidation of phospholipids containing polyunsaturated fatty acids. Ferroptosis has been associated with a number of diseases, including cancers such as hepatocellular carcinoma, breast cancer, acute renal damage and neurological disorders such as Alzheimer's disease and Alzheimer's disease, and there may be an association between ferroptosis and acute myeloid leukemia (AML). The present review aims to describe the primary regulatory pathways of ferroptosis, and the relationship between ferroptosis and the occurrence and development of AML. Furthermore, the present review comprehensively summarizes the latest advances in the treatment and prognosis of ferroptosis in AML.
铁死亡是一种相对较新发现的受调控的细胞死亡类型，由铁依赖性脂质过氧化作用诱导。铁死亡的关键促成因素包括：逆转脂质过氧化作用所需的谷胱甘肽过氧化物酶4的缺失、氧化还原活性铁的积累以及含有多不饱和脂肪酸的磷脂的氧化。铁死亡与多种疾病相关，包括肝细胞癌、乳腺癌等癌症、急性肾损伤以及阿尔茨海默病等神经疾病，并且铁死亡与急性髓系白血病（AML）之间可能存在关联。本综述旨在描述铁死亡的主要调控途径，以及铁死亡与AML发生发展之间的关系。此外，本综述全面总结了AML中铁死亡治疗和预后的最新进展。
