使用莫里斯水迷宫试验评估鱼油补充剂对毛果芸香碱诱导的癫痫大鼠空间记忆的影响。
Effects of fish oil supplementation on spatial memory in rats with pilocarpine-induced epilepsy assessed using the Morris Water Maze test.
作者信息
Bocca Nejm Mariana, Victorino Daniella Balduino, Guimarães-Marques Marcia Jonathas, Scorza Carla Alessandra, Finsterer Josef, Scorza Fulvio Alexandre, Cysneiros Roberta Monterazzo
机构信息
Disciplina de Neurociência, Departamento de Neurologia e Neurocirurgia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Krankenanstalt Rudolfstiftung, Messerli Institute, Veterinary University of Vienna, Vienna, Austria.
出版信息
Epileptic Disord. 2021 Jun 1;23(3):476-484. doi: 10.1684/epd.2021.1289.
OBJECTIVE
Patients with temporal lobe epilepsy (TLE) are at high risk of experiencing cognitive impairment. Such dysfunction is also observed in an animal model of TLE, the rat model of pilocarpine-induced epilepsy.
METHODS
We investigated the effects of fish oil supplementation on spatial memory in rats with pilocarpine-induced epilepsy using the Morris Water Maze (MWM) test.
RESULTS
Although rats with pilocarpine-induced epilepsy treated with fish oil learned the platform location significantly faster by Day 7 of the acquisition phase, spatial memory performance of these rats was unaffected by fish oil supplementation during probe trials.
SIGNIFICANCE
Our study provides insights into the importance of considering nutraceutical strategies for enhancing cognitive abilities in patients with TLE.
目的
颞叶癫痫（TLE）患者有发生认知障碍的高风险。在TLE的动物模型——毛果芸香碱诱导癫痫的大鼠模型中也观察到了这种功能障碍。
方法
我们使用莫里斯水迷宫（MWM）试验研究了补充鱼油对毛果芸香碱诱导癫痫大鼠空间记忆的影响。
结果
虽然在训练阶段第7天时，用鱼油治疗的毛果芸香碱诱导癫痫大鼠显著更快地学会了平台位置，但在探索试验期间，这些大鼠的空间记忆表现并未受到补充鱼油的影响。
意义
我们的研究为考虑采用营养策略提高TLE患者认知能力的重要性提供了见解。
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