Department of Internal Medicine, Houston Methodist Hospital, Houston, TX, USA.
Department of Oncology, Houston Methodist Cancer Center, Houston, TX, USA.
Clin Exp Dermatol. 2021 Dec;46(8):1420-1426. doi: 10.1111/ced.14777. Epub 2021 Jul 17.
Primary cutaneous anaplastic large-cell lymphoma (PC-ALCL) is a rare T-cell lymphoma. A prior analysis of the Surveillance, Epidemiology, and End Results (SEER) database reported only 157 cases of localized primary cutaneous CD30+ T-cell lymphoproliferative disorders (PC-ALCL and lymphomatoid papulosis) from 1973 to 2004. Our analysis of the SEER database since 2004 is the largest to date and our results improve our understanding of this disease and their potential prognostic factors.
We used the SEER database to retrospectively identify patients. Survival was analysed using the Kaplan-Meier method, and log-rank tests were used to compare survival distributions.
There were 501 cases of PC-ALCL recorded from 2005 to 2016. Overall survival rates at 5 and 10 years were found to be 80.6% (95% CI 76.3%-84.3%) and 61.5% (95% CI 54.1%-68.1%) respectively. Age ≥ 60 years [hazard ratio (HR) = 1.09, P = 0.001 and use of chemotherapy (HR = 1.86, P = 0.01)] were associated with lower overall survival. In contrast to the 1973-2004 cohort, the head and neck site was not significantly associated with prognosis on multivariate analysis.
PC-ALCL has been increasingly recognized over the past decade. Age > 60 years and use of chemotherapy are associated with a worse outcome. Contrary to prior studies, location was not associated with poor survival.
原发性皮肤间变性大细胞淋巴瘤（PC-ALCL）是一种罕见的 T 细胞淋巴瘤。对监测、流行病学和最终结果（SEER）数据库的先前分析报告称，1973 年至 2004 年间，仅有 157 例局部原发性皮肤 CD30+T 细胞淋巴增生性疾病（PC-ALCL 和淋巴母细胞性丘疹病）。我们对自 2004 年以来 SEER 数据库的分析是迄今为止最大的一次，我们的研究结果提高了对这种疾病及其潜在预后因素的认识。
我们使用 SEER 数据库进行回顾性患者识别。使用 Kaplan-Meier 法分析生存情况，对数秩检验用于比较生存分布。
2005 年至 2016 年期间共记录了 501 例 PC-ALCL 病例。5 年和 10 年的总生存率分别为 80.6%（95%CI 76.3%-84.3%）和 61.5%（95%CI 54.1%-68.1%）。年龄≥60 岁[风险比（HR）=1.09，P=0.001]和化疗的使用[HR=1.86，P=0.01]与总生存率降低相关。与 1973-2004 队列相比，多因素分析中头颈部部位与预后无显著相关性。
在过去十年中，PC-ALCL 越来越受到重视。年龄>60 岁和化疗的使用与预后较差相关。与先前的研究相反，位置与不良生存无关。
