Paul Sujay, Bravo Vázquez Luis Alberto, Uribe Samantha Pérez, Manzanero Cárdenas Luis Aarón, Ruíz Aguilar María Fernanda, Chakraborty Samik, Sharma Ashutosh
Tecnologico de Monterrey, School of Engineering and Sciences, Campus Queretaro, Av. Epigmenio Gonzalez, No. 500 Fracc, San Pablo, CP 76130, Querétaro, Mexico.
Tecnologico de Monterrey, School of Engineering and Sciences, Campus Queretaro, Av. Epigmenio Gonzalez, No. 500 Fracc, San Pablo, CP 76130, Querétaro, Mexico.
Biochimie. 2021 Aug;187:83-93. doi: 10.1016/j.biochi.2021.05.015. Epub 2021 Jun 1.
MicroRNAs (miRNAs) are small (∼21 nucleotides), endogenous, non-coding RNA molecules implicated in the post-transcriptional gene regulation performed through target mRNA cleavage or translational inhibition. In recent years, several investigations have demonstrated that miRNAs are involved in regulating both carbohydrate and lipid homeostasis in humans and other organisms. Moreover, it has been observed that the dysregulation of these metabolism-related miRNAs leads to the development of several metabolic disorders, such as type 2 diabetes, obesity, nonalcoholic fatty liver, insulin resistance, and hyperlipidemia. Hence, in this current review, with the aim to impulse the research arena of the micro-transcriptome implications in vital metabolic pathways as well as to highlight the remarkable potential of miRNAs as therapeutic targets for metabolic disorders in humans, we provide an overview of the regulatory roles of metabolism-associated miRNAs in humans and murine models.
微小RNA（miRNA）是小的（约21个核苷酸）内源性非编码RNA分子，通过靶mRNA切割或翻译抑制参与转录后基因调控。近年来，多项研究表明，miRNA参与调节人类和其他生物体中的碳水化合物和脂质稳态。此外，已经观察到这些与代谢相关的miRNA的失调会导致多种代谢紊乱的发生，如2型糖尿病、肥胖症、非酒精性脂肪肝、胰岛素抵抗和高脂血症。因此，在本综述中，为了推动微转录组在重要代谢途径中的研究领域，并突出miRNA作为人类代谢紊乱治疗靶点的巨大潜力，我们概述了代谢相关miRNA在人类和小鼠模型中的调控作用。
