College of Food and Bioengineering, Fujian Polytechnic Normal University, Fuqing, 350300, China; College of Life Science, Fujian Normal University, Fuzhou, 350117, China.
College of Food and Bioengineering, Fujian Polytechnic Normal University, Fuqing, 350300, China.
Food Chem Toxicol. 2021 Aug;154:112315. doi: 10.1016/j.fct.2021.112315. Epub 2021 Jun 1.
Acrylamide has a variety of toxicities, including carcinogenicity, and can be present in food via the Maillard reaction in processing of certain foods. Previous studies have demonstrated that co-existing Maillard reaction products (MRPs) ameliorated acrylamide-induced abnormal physiological status in mice. This study is focused on the effects on hematological parameters, erythrocyte osmotic fragility, oxidative stress in plasma and liver, and contents of 8-hydroxy-2-deoxyguanosine (8-OHdG) in mice exposed to acrylamide and to acrylamide and MRPs derived from arginine and glucose. Acrylamide alone caused significant increases in liver indexes, erythrocyte osmotic fragility, malonaldehyde level in liver and 8-OHdG level in testis, and significant decreases in weight gain, hematological parameters, levels of glutathione, glutathione peroxidase and total superoxide dismutase in plasma. Whether MRPs and acrylamide were physically mixed or when the solution is prepared from heating the mixture of arginine, glucose and acrylamide, the presence of MRPs effectively reduced the adverse changes caused by acrylamide. These results suggest that the toxicity of acrylamide to mice can be ameliorated by MRPs, the common compositions simultaneously generated with acrylamide in food matrix.
丙烯酰胺具有多种毒性，包括致癌性，并且可以通过某些食品加工中的美拉德反应存在于食品中。先前的研究表明，共存的美拉德反应产物（MRP）可以改善丙烯酰胺诱导的小鼠异常生理状态。本研究集中于丙烯酰胺和由精氨酸和葡萄糖衍生的丙烯酰胺和 MRP 暴露于小鼠对血液学参数、红细胞渗透脆性、血浆和肝脏氧化应激以及 8-羟基-2-脱氧鸟苷（8-OHdG）含量的影响。丙烯酰胺单独使用会导致肝脏指数、红细胞渗透脆性、肝脏丙二醛水平和睾丸 8-OHdG 水平显著升高，体重增加、血液学参数、血浆中谷胱甘肽、谷胱甘肽过氧化物酶和总超氧化物歧化酶水平显著降低。无论 MRP 和丙烯酰胺是物理混合还是从加热精氨酸、葡萄糖和丙烯酰胺混合物制备溶液时，MRP 的存在都有效地减少了丙烯酰胺引起的不良变化。这些结果表明，MRP 可以减轻丙烯酰胺对小鼠的毒性，MRP 是食品基质中与丙烯酰胺同时生成的常见成分。
