Rocha Tauana Ogata Coelho da, Moya Fernanda Gonçalves, Vilella Vívian Moreira, Lellis Rute Facchini
Department of Dermatology, Complexo Hospitalar Heliópolis, São Paulo, SP, Brazil.
Department of Pathology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
An Bras Dermatol. 2021 Jul-Aug;96(4):454-457. doi: 10.1016/j.abd.2020.12.006. Epub 2021 Jun 1.
Currently, pagetoid dyskeratosis is believed to involve an accelerated keratinization process, possibly induced by mechanical trauma. It represents, in almost its totality, incidental histological findings of specific cells, except when it occurs in the hands, where it usually occurs simultaneously with skin lesions and local dyschromia. These are large, rounded keratinocytes, with pale cytoplasm and a pyknotic nucleus surrounded by a clear halo, which can be easily mistaken by other skin diseases. Its etiology is not completely elucidated, and the correct identification of this entity can be of great importance in the differential diagnosis of skin disorders and the understanding of the keratinization process of the epidermis.
目前，派杰样角化不良被认为涉及一个加速的角质化过程，可能由机械性创伤诱发。几乎在所有情况下，它都表现为特定细胞的偶然组织学发现，除非发生在手部，在手部它通常与皮肤病变和局部色素异常同时出现。这些细胞是大的圆形角质形成细胞，细胞质淡染，核固缩，周围有清晰的晕圈，很容易被误诊为其他皮肤病。其病因尚未完全阐明，正确识别这一实体对于皮肤疾病的鉴别诊断以及理解表皮角质化过程可能具有重要意义。
