Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan
Anticancer Res. 2021 Jun;41(6):2993-2999. doi: 10.21873/anticanres.15081.
BACKGROUND/AIM: The delayed initiation of treatment is not associated with good clinical outcomes in patients with malignancies. However, few previous studies have examined prognostic factors, including the delayed initiation of treatment, in malignant bone tumors.
One hundred and one patients with malignant bone tumors were enrolled. Univariate and multivariate analyses were performed to identify factors predicting metastasis, including factors that delay the initiation of treatment.
The multivariate analysis revealed that high-grade bone malignancy (p<0.01), a >30-day delay in referral to a specialized hospital by a general practitioner (p=0.03), and large tumor size (>77 mm) (p=0.04), were independently associated with metastasis of malignant bone tumors.
When general practitioners notice a patient with a >77 mm bone tumor, early referral to a specialized hospital within one month might be essential for preventing metastasis.
背景/目的：在恶性肿瘤患者中，治疗开始时间的延迟与临床结局不佳无关。然而，以前很少有研究检查包括治疗开始时间延迟在内的恶性骨肿瘤的预后因素。
共纳入 101 例恶性骨肿瘤患者。进行单因素和多因素分析，以确定转移的预测因素，包括延迟治疗开始的因素。
多因素分析显示，高级别骨恶性肿瘤（p<0.01）、全科医生转介至专科医院的时间延迟>30 天（p=0.03）以及肿瘤较大（>77mm）（p=0.04）与恶性骨肿瘤的转移独立相关。
当全科医生发现>77mm 骨肿瘤的患者时，在一个月内尽早将其转介至专科医院可能对预防转移至关重要。
