治疗时机延迟与恶性骨肿瘤转移相关。

Delayed Initiation of Treatment Is Associated With Metastasis of Malignant Bone Tumor.

机构信息

Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.

Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan

出版信息

Anticancer Res. 2021 Jun;41(6):2993-2999. doi: 10.21873/anticanres.15081.

DOI:10.21873/anticanres.15081

PMID:34083290

Abstract

BACKGROUND/AIM: The delayed initiation of treatment is not associated with good clinical outcomes in patients with malignancies. However, few previous studies have examined prognostic factors, including the delayed initiation of treatment, in malignant bone tumors.

PATIENTS AND METHODS

One hundred and one patients with malignant bone tumors were enrolled. Univariate and multivariate analyses were performed to identify factors predicting metastasis, including factors that delay the initiation of treatment.

RESULTS

The multivariate analysis revealed that high-grade bone malignancy (p<0.01), a >30-day delay in referral to a specialized hospital by a general practitioner (p=0.03), and large tumor size (>77 mm) (p=0.04), were independently associated with metastasis of malignant bone tumors.

CONCLUSION

When general practitioners notice a patient with a >77 mm bone tumor, early referral to a specialized hospital within one month might be essential for preventing metastasis.

摘要

背景/目的：在恶性肿瘤患者中，治疗开始时间的延迟与临床结局不佳无关。然而，以前很少有研究检查包括治疗开始时间延迟在内的恶性骨肿瘤的预后因素。