Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan
Anticancer Res. 2020 Dec;40(12):7009-7015. doi: 10.21873/anticanres.14726.
BACKGROUND/AIM: The delayed initiation of treatment is associated with poor clinical outcomes in patients with malignancies. However, few previous studies have investigated prognostic factors, including the delayed initiation of treatment, in soft-tissue sarcoma.
One hundred and fifty-three patients with soft-tissue sarcoma were enrolled. Univariate and multivariate analyses were performed to identify factors predicting metastasis, including factors that delay the initiation of treatment.
The multivariate analysis revealed that high histological grade (p<0.01), tumor located in the trunk (p=0.04), >5-month delay from symptom initiation to consultation of general practitioner (p=0.02), and >29-day delay in referral to a specialized hospital by general practitioners (p=0.03) were independently associated with metastasis of soft tissue sarcoma.
Early consultation of a general practitioner and early referral to a specialized hospital might be essential for preventing metastasis of soft-tissue sarcoma.
背景/目的：恶性肿瘤患者治疗的延迟启动与较差的临床结局相关。然而，此前很少有研究调查软组织肉瘤的预后因素，包括治疗的延迟启动。
共纳入 153 名软组织肉瘤患者。进行单因素和多因素分析，以确定包括治疗延迟启动在内的转移预测因素。
多因素分析显示，高组织学分级（p<0.01）、肿瘤位于躯干（p=0.04）、从症状出现到全科医生就诊的时间超过 5 个月（p=0.02）以及全科医生转介至专科医院的时间超过 29 天（p=0.03）与软组织肉瘤的转移独立相关。
早期向全科医生咨询以及早期向专科医院转介可能对预防软组织肉瘤转移至关重要。
