促炎细胞因子与前列腺癌的诊断有关吗？
Are Proinflammatory Cytokines Relevant for the Diagnosis of Prostate Cancer?
机构信息
Department of Clinical Pathology, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal;
Department of Laboratory Medicine, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.
出版信息
Anticancer Res. 2021 Jun;41(6):3067-3073. doi: 10.21873/anticanres.15090.
BACKGROUND/AIM: Inflammation plays an important role in prostate cancer (PCa). We evaluated proinflammatory cytokines regarding differential diagnosis of PCa in men with PSA levels between 2-10 ng/ml.
PATIENTS AND METHODS
Serum samples of 79 men (PSA 2-10 ng/ml) were analyzed for 10 proinflammatory cytokines (IL-6, IL-8, TNF-α, IFN-γ, IL-10, IL-1β, IL-2, IL-4, IL-12p70, IL-13) and results were evaluated regarding presence of PCa and disease severity.
RESULTS
Significant differences between PCa patients and controls were found for IL-6 (p=0.002), IL-8 (p=0.030), and TNF-α (p=0.009), although they were not predictors of PCa in a logistic regression analysis. In addition, IL-6 and TNF-α levels were significantly higher in patients with high-risk PCa (p<0.05). No significant differences were observed regarding the other cytokines.
CONCLUSION
In patients with PSA levels between 2-10 ng/ml, IL-6, IL-8, and TNF-α are associated with PCa, and IL-6 and TNF-α are associated with high-risk PCa.
背景/目的：炎症在前列腺癌（PCa）中起着重要作用。我们评估了促炎细胞因子在 PSA 水平为 2-10ng/ml 的男性中对 PCa 的鉴别诊断中的作用。
患者和方法
分析了 79 名男性（PSA 2-10ng/ml）的血清样本中的 10 种促炎细胞因子（IL-6、IL-8、TNF-α、IFN-γ、IL-10、IL-1β、IL-2、IL-4、IL-12p70、IL-13），并评估了它们在 PCa 存在和疾病严重程度方面的结果。
结果
PCa 患者与对照组之间的 IL-6（p=0.002）、IL-8（p=0.030）和 TNF-α（p=0.009）存在显著差异，但在逻辑回归分析中它们并不是 PCa 的预测因子。此外，高风险 PCa 患者的 IL-6 和 TNF-α 水平显著升高（p<0.05）。其他细胞因子没有观察到显著差异。
结论
在 PSA 水平为 2-10ng/ml 的患者中，IL-6、IL-8 和 TNF-α 与 PCa 相关，而 IL-6 和 TNF-α 与高风险 PCa 相关。
Zotero 插件