Laboratory of Cellular Oncology, National Cancer Institute, NIH, Bethesda, MD 20892.
Laboratory of Cellular Oncology, National Cancer Institute, NIH, Bethesda, MD 20892
Proc Natl Acad Sci U S A. 2021 Jun 8;118(23). doi: 10.1073/pnas.2023202118. Epub 2021 Jun 3.
Despite remarkable strides in microbiome research, the viral component of the microbiome has generally presented a more challenging target than the bacteriome. This gap persists, even though many thousands of shotgun sequencing runs from human metagenomic samples exist in public databases, and all of them encompass large amounts of viral sequence data. The lack of a comprehensive database for human-associated viruses has historically stymied efforts to interrogate the impact of the virome on human health. This study probes thousands of datasets to uncover sequences from over 45,000 unique virus taxa, with historically high per-genome completeness. Large publicly available case-control studies are reanalyzed, and over 2,200 strong virus-disease associations are found.
尽管在微生物组研究方面取得了显著进展，但微生物组中的病毒成分通常比细菌组更具挑战性。即使在公共数据库中存在数以千计的人类宏基因组样本的鸟枪法测序结果，并且它们都包含大量的病毒序列数据，但这一差距仍然存在。缺乏一个全面的人类相关病毒数据库，一直以来都阻碍了人们探究病毒组对人类健康影响的努力。本研究对数千个数据集进行了探测，揭示了超过 45000 个独特病毒分类群的序列，具有历史上较高的每个基因组完整度。对大型公开的病例对照研究进行了重新分析，发现了超过 2200 个强有力的病毒-疾病关联。
