Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
BluAct Technologies GmbH, Zurich, Switzerland.
Nat Nanotechnol. 2021 Aug;16(8):918-925. doi: 10.1038/s41565-021-00920-5. Epub 2021 Jun 3.
Minimizing the spread of viruses in the environment is the first defence line when fighting outbreaks and pandemics, but the current COVID-19 pandemic demonstrates how difficult this is on a global scale, particularly in a sustainable and environmentally friendly way. Here we introduce and develop a sustainable and biodegradable antiviral filtration membrane composed of amyloid nanofibrils made from food-grade milk proteins and iron oxyhydroxide nanoparticles synthesized in situ from iron salts by simple pH tuning. Thus, all the membrane components are made of environmentally friendly, non-toxic and widely available materials. The membrane has outstanding efficacy against a broad range of viruses, which include enveloped, non-enveloped, airborne and waterborne viruses, such as SARS-CoV-2, H1N1 (the influenza A virus strain responsible for the swine flu pandemic in 2009) and enterovirus 71 (a non-enveloped virus resistant to harsh conditions, such as highly acidic pH), which highlights a possible role in fighting the current and future viral outbreaks and pandemics.
在应对疫情爆发和大流行时，最大限度地减少病毒在环境中的传播是第一道防线，但当前的 COVID-19 大流行表明，在全球范围内，特别是以可持续和环保的方式做到这一点是多么困难。在这里，我们介绍并开发了一种由食物级牛奶蛋白制成的淀粉样原纤维纳米纤维和通过简单的 pH 调谐从铁盐原位合成的铁氧羟基纳米粒子组成的可持续和可生物降解的抗病毒过滤膜。因此，所有膜组件均由环保、无毒且广泛可用的材料制成。该膜对多种病毒具有出色的功效，包括包膜病毒、非包膜病毒、空气传播病毒和水传播病毒，例如 SARS-CoV-2、H1N1（导致 2009 年猪流感大流行的甲型流感病毒株）和肠道病毒 71（一种对恶劣条件具有抵抗力的非包膜病毒，如高度酸性 pH 值），这突显了其在应对当前和未来病毒爆发和大流行方面的潜在作用。
