甲状腺原发性朗格汉斯细胞组织细胞增多症
Primary Langerhans Cell Histiocytosis in Thyroid.
作者信息
Dursun A, Pala E E, Ugurlu L, Aydin C
机构信息
Izmir Tepecik Training and Research Hospital - General Surgery, Izmir, Turkey.
Pathology, Izmir, Turkey.
出版信息
Acta Endocrinol (Buchar). 2020 Oct-Dec;16(4):501-504. doi: 10.4183/aeb.2020.501.
BACKGROUND
Langerhans cell histiocytosis (LCH) is a rare group of neoplastic diseases resulting from Langerhans dendritic cells. The most common site (80%) is bones. Thyroid gland involvement is exceedingly rare and usually expected to be seen as a part of multisystemic disease.
CASE REPORT
We present a 45 year old male patient operated due to multinodular goiter and neck pain, and diagnosed with LCH in his postoperative pathologic examination. As a result of the systemic screening performed after the pathological diagnosis, the disease was interestingly localized to the thyroid gland. Systemic involvement did not develop in the two-year follow-up of the patient who did not receive additional chemotherapy treatment.
CONCLUSION
It is difficult to diagnose LCH in the thyroid gland before surgery. Although surgical treatment with or without chemotherapy is recommended, surgery is not recommended alone since it is generally systemic involvement. However, in primary thyroid LCH cases limited to the thyroid gland, we recommend that only total thyroidectomy treatment should be kept in mind.
背景
朗格汉斯细胞组织细胞增多症（LCH）是一组由朗格汉斯树突状细胞引起的罕见肿瘤性疾病。最常见的发病部位（80%）是骨骼。甲状腺受累极为罕见，通常被视为多系统疾病的一部分。
病例报告
我们报告一名45岁男性患者，因多结节性甲状腺肿和颈部疼痛接受手术治疗，术后病理检查诊断为LCH。病理诊断后进行的全身筛查结果显示，有趣的是，该疾病局限于甲状腺。在未接受额外化疗的患者两年随访中未出现全身受累情况。
结论
术前很难诊断甲状腺LCH。虽然推荐进行手术治疗，可联合或不联合化疗，但由于该病通常有全身受累情况，不建议单独进行手术。然而，对于仅限于甲状腺的原发性甲状腺LCH病例，我们建议仅考虑行甲状腺全切除术治疗。
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