甲状腺孤立性朗格汉斯细胞组织细胞增多症：一例报告并文献复习
Solitary langerhans histiocytosis of the thyroid gland: a case report and literature review.
作者信息
Patten Darren K, Wani Zubair, Tolley Neil
机构信息
Department of Biosurgery and Surgical Oncology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, W2 1NY, UK.
出版信息
Head Neck Pathol. 2012 Jun;6(2):279-89. doi: 10.1007/s12105-011-0321-8. Epub 2011 Dec 24.
Abstract
Langerhans cell histiocytosis (LCH) is a rare disease of antigen presenting cells, with an incidence rate of 4.0-5.4 per 1 million individuals. The most common endocrinological manifestation of classical LCH is associated with the posterior pituitary, presenting as Diabetes Insipidus. However, LCH can affect multiple organs and classification is based on the body system involvement. The disease is confirmed by electron microscopy or immunohistochemical reactivity of histiocytes to CD1a and/or S100. LCH rarely involves the thyroid gland, and management of such disease is controversial. Current literature documents 65 English language reported cases of LCH involving the thyroid gland. We present an unusual case of LCH of the thyroid gland, with variable diagnoses on fine needle aspiration (FNA) cytology, and literature review of all English reported cases.
摘要
朗格汉斯细胞组织细胞增多症（LCH）是一种罕见的抗原呈递细胞疾病，发病率为每100万人中有4.0 - 5.4例。经典LCH最常见的内分泌表现与垂体后叶有关，表现为尿崩症。然而，LCH可累及多个器官，其分类基于受累的身体系统。该疾病通过组织细胞对CD1a和/或S100的电子显微镜检查或免疫组化反应性得以确诊。LCH很少累及甲状腺，对此类疾病的治疗存在争议。目前的文献记载了65例英文报道的累及甲状腺的LCH病例。我们报告了一例不寻常的甲状腺LCH病例，细针穿刺（FNA）细胞学检查有多种诊断结果，并对所有英文报道病例进行了文献综述。
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