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光动力疗法作为治疗年轻患者带状疱疹病毒感染的首选方法:病例报告。

Antimicrobial Photodynamic Therapy Used as First Choice to Treat Herpes Zoster Virus Infection in Younger Patient: A Case Report.

机构信息

Department of Onco-Hematological Pediatric, Perez Scremini Foundation, Montevideo, Uruguay.

Clinician of Special Laboratory of Laser in Dentistry (LELO), School of Dentistry, University of São Paulo (USP), São Paulo, Brazil.

出版信息

Photobiomodul Photomed Laser Surg. 2020 Apr;38(4):232-236. doi: 10.1089/photob.2019.4725.

Abstract

Herpes zoster virus infection is commonly described as reactivation of the varicella zoster virus (VZV), which involves the trigeminal nerve branches and ganglia in the maxillofacial region. The ophthalmic branch is the most involved, whereas the maxillary (V2) and mandibular (V3) dermatomes are less commonly affected. This report describes the positive clinical results of photodynamaic therapy (PDT), used as first choice treatment modality, in a younger female patient who showed a diagnosis of recurrent infection of VZV in the right cheek after five applications and without having undergone medical approach. PDT has been used to treat several infectious processes and pre-oncological intraoral and extra-oral lesions. Our first-choice treatment protocol, taking into account her medical record, was PDT until we obtained completely regression and recovery. On the third and fourth days after light irradiation, the energy was reduced to 4 J. At fifth day of light irradiation, complete recovery was clinically observed. The treatment with low-intensity laser, for both aPDT and light irradiation, was effective and safe, resulting in decontamination and healing of the area of the affected lesion, and improvement in the signs and symptoms of herpes zoster virus.

摘要

带状疱疹病毒感染通常被描述为水痘带状疱疹病毒(VZV)的再激活,涉及面颌部的三叉神经分支和神经节。眼支是最常受累的,而上颌(V2)和下颌(V3)皮节则较少受累。本报告描述了光动力学疗法(PDT)作为首选治疗方式在年轻女性患者中的阳性临床效果,该患者在右侧脸颊出现 VZV 复发性感染,经过五次应用且未进行医学治疗后显示出积极的临床结果。PDT 已被用于治疗多种感染性疾病以及口腔内和口腔外的前癌性病变。根据她的病历,我们的首选治疗方案是 PDT,直到我们获得完全消退和恢复。在光照射后的第三和第四天,能量降低到 4 J。在第五天的光照射后,临床观察到完全恢复。低强度激光治疗,无论是 aPDT 还是光照射,都是有效和安全的,导致受影响病变区域的净化和愈合,并改善了带状疱疹病毒的症状和体征。

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