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在一名HIV感染患者中联合使用克林霉素和阿奇霉素治疗弓形虫性脑炎：病例报告

Treatment of toxoplasmic encephalitis with the combination of clindamycin plus azithromycin in an HIV-infected patient: A case report.

作者信息

Mohammadi Keyhan, Khalili Hossein, Jafari Sirous, Yaribash Shakila

机构信息

Department of Clinical Pharmacy Faculty of Pharmacy Tehran University of Medical Sciences Tehran Iran.

Department of Infectious Diseases Faculty of Medicine Tehran University of Medical Sciences Tehran Iran.

出版信息

Clin Case Rep. 2021 Mar 24;9(5):e04045. doi: 10.1002/ccr3.4045. eCollection 2021 May.

DOI:10.1002/ccr3.4045
PMID:34084486
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8142398/
Abstract

The existence of alternative oral therapies could help clinicians to treat toxoplasmic encephalitis (TE) in the HIV patients. The combination of azithromycin and clindamycin may serve as an effective treatment for TE in HIV-infected patients.

摘要

其他口服疗法的存在有助于临床医生治疗艾滋病患者的弓形虫脑炎（TE）。阿奇霉素和克林霉素联合使用可能是治疗艾滋病感染患者TE的有效方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37c2/8142398/d855ace8aa36/CCR3-9-e04045-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37c2/8142398/d855ace8aa36/CCR3-9-e04045-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37c2/8142398/d855ace8aa36/CCR3-9-e04045-g002.jpg

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本文引用的文献

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Emerg Infect Dis. 2019 Apr;25(4):841-843. doi: 10.3201/eid2504.181689.
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Continuum (Minneap Minn). 2018 Oct;24(5, Neuroinfectious Disease):1397-1421. doi: 10.1212/CON.0000000000000647.
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Treatment of Toxoplasmosis: Historical Perspective, Animal Models, and Current Clinical Practice.
弓形虫病的治疗：历史视角、动物模型和当前临床实践。
Clin Microbiol Rev. 2018 Sep 12;31(4). doi: 10.1128/CMR.00057-17. Print 2018 Oct.
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Life-Threatening Thrombocytopenia Secondary to Trimethoprim/Sulfamethoxazole.甲氧苄啶/磺胺甲恶唑继发的危及生命的血小板减少症
Cureus. 2017 Dec 19;9(12):e1963. doi: 10.7759/cureus.1963.
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HIV-associated opportunistic CNS infections: pathophysiology, diagnosis and treatment.HIV 相关机会性中枢神经系统感染：发病机制、诊断与治疗。
Nat Rev Neurol. 2016 Oct 27;12(11):662-674. doi: 10.1038/nrneurol.2016.149.
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Toxoplasmosis in HIV infection: An overview.HIV感染中的弓形虫病：概述
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HIV Med. 2017 Feb;18(2):115-124. doi: 10.1111/hiv.12402. Epub 2016 Jun 28.
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