Dati F, Becker U
Research Laboratories of Behringwerke AG, Marburg, W.-Germany.
Behring Inst Mitt. 1988 Apr(82):309-24.
Recently, recommendations for the production of thromboplastins have been issued by International Committees (ICSH/ICTH) to achieve a standardization of prothrombin time assays. Following such recommendations we have standardized two new PT reagents based on coagulometric and photometric methods which rely on the same sensitive human placental thromboplastin. Both PT reagents have been optimized especially for use in oral anticoagulant therapy. They offer high sensitivity and reproducibility, accurate lot standardization and therefore internationally comparable values by the expression of the ISI value of each reagent batch.
最近，国际委员会（ICSH/ICTH）发布了有关凝血活酶生产的建议，以实现凝血酶原时间测定的标准化。遵循这些建议，我们基于凝固法和光度法对两种新型PT试剂进行了标准化，这两种方法均依赖于同一种灵敏的人胎盘凝血活酶。两种PT试剂均经过优化，特别适用于口服抗凝治疗。它们具有高灵敏度和可重复性，批次标准化准确，因此通过各试剂批次的国际敏感度指数（ISI）值的表达可获得国际可比数值。
