Dixey J J, Noormohamed F H, Lant A F, Brewerton D A
Department of Rheumatology, Charing Cross and Westminster Medical School, London.
Br J Clin Pharmacol. 1988 May;25(5):614-7. doi: 10.1111/j.1365-2125.1988.tb03355.x.
The renal response to a challenge of maximal water diuresis has been studied in seven subjects pretreated over 48 h with either placebo, probenecid, indomethacin or piroxicam. Probenecid did not alter the excretion of water and sodium chloride when compared with placebo responses, but increased both phosphate and urate clearances. Indomethacin reduced significantly both water and sodium chloride clearances by approximately 40%. Piroxicam reduced water excretion to a similar extent but did not influence salt output. In parallel with these changes, both drugs caused significant phosphaturia. It is concluded that the renal actions of nonsteroidal anti-inflammatory drugs (NSAIDs) are individually distinct and involve direct effects on tubular transport of ions and water to differing extents within both the proximal and distal portions of the nephron.
在七名受试者中研究了肾脏对最大程度水利尿刺激的反应，这些受试者在48小时内分别接受了安慰剂、丙磺舒、吲哚美辛或吡罗昔康预处理。与安慰剂反应相比，丙磺舒并未改变水和氯化钠的排泄，但增加了磷酸盐和尿酸盐清除率。吲哚美辛使水和氯化钠清除率均显著降低约40%。吡罗昔康使水排泄减少到类似程度，但不影响盐的排出。与这些变化同时发生的是，两种药物均引起显著的磷酸盐尿。得出的结论是，非甾体抗炎药（NSAIDs）的肾脏作用各有不同，并且在肾单位的近端和远端部分对离子和水的肾小管转运有不同程度的直接影响。
