Bonhomme M, Favre L, Vallotton M B
Acta Endocrinol (Copenh). 1983 Jul;103(3):331-6. doi: 10.1530/acta.0.1030331.
To examine the influence of prostaglandins (PGs) and sodium-volume status on the urinary excretion and action of arginine-vasopressin (AVP), we studied the response to a hypertonic saline infusion (2.5% NaCl, 0.06 ml/kg/min for 3 h) in 8 healthy males under three different conditions: 1) on an ad libitum salt diet (C), 2) after 4-day treatment with indomethacin (IDM) 150 mg/d, 3) after 4-day treatment with fluorohydrocortisone (9 alpha FF) 0.6 mg/d. The rise of urine osmolality and the decrease of free water clearance were identical in all three studies. Basal urinary PGE2, PGF2 alpha and AVP were decreased during IDM and unchanged during 9 alpha FF, compared to C. The increment of urinary AVP was similar during C and IDM but significantly greater with 9 alpha FF (P less than 0.02) although urinary PGs were higher at the end of the infusion. In conclusion, despite markedly different hormonal patterns and sodium status in the three protocols, the antidiuretic response to an osmolar load is preserved suggesting an adaptive mechanism maintaining a constant balance between AVP and PGs.
为研究前列腺素（PGs）和钠容量状态对精氨酸血管加压素（AVP）尿排泄及作用的影响，我们在8名健康男性中，于三种不同情况下研究了对高渗盐水输注（2.5% NaCl，0.06 ml/kg/min，共3小时）的反应：1）自由摄盐饮食（C组）；2）吲哚美辛（IDM）150 mg/d治疗4天后；3）氟氢可的松（9αFF）0.6 mg/d治疗4天后。在所有三项研究中，尿渗透压升高和自由水清除率降低情况相同。与C组相比，IDM治疗期间基础尿PGE2、PGF2α和AVP降低，9αFF治疗期间则无变化。C组和IDM治疗期间尿AVP的增量相似，但9αFF组显著更大（P<0.02），尽管输注结束时尿PGs更高。总之，尽管三种方案中的激素模式和钠状态明显不同，但对渗透压负荷的抗利尿反应得以保留，提示存在一种适应性机制维持AVP和PGs之间的恒定平衡。
