Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Center for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Center for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
J Pediatr. 2021 Oct;237:87-95.e1. doi: 10.1016/j.jpeds.2021.05.058. Epub 2021 Jun 1.
To determine the association of number of siblings on cardiovascular risk factors in childhood and in adulthood.
In total, 3554 participants (51% female) from the Cardiovascular Risk in Young Finns Study with cardiovascular disease risk factor data at baseline 1980 (age 3-18 years) and 2491 participants with longitudinal risk factor data at the 2011 follow-up. Participants were categorized by number of siblings at baseline (0, 1, or more than 1). Risk factors (body mass index, physical activity, hypertension, dyslipidemia, and overweight, and metabolic syndrome) in childhood and in adulthood were used as outcomes. Analyses were adjusted for age and sex.
In childhood, participants without siblings had higher body mass index (18.2 kg/m, 95% CI 18.0-18.3) than those with 1 sibling (17.9 kg/m, 95% CI 17.8-18.0) or more than 1 sibling (17.8 kg/m, 95% CI 17.7-17.9). Childhood physical activity index was lower among participants without siblings (SD -0.08, 95% CI -0.16-0.00) compared with participants with 1 sibling (SD 0.06, 95%CI 0.01-0.11) or more than 1 sibling (SD -0.02, 95% CI -0.07-0.03). OR for adulthood hypertension was lower among participants with 1 sibling (OR 0.73, 95% CI 0.54-0.98) and more than 1 sibling (OR 0.71, 95% CI 0.52-0.97) compared with participants with no siblings. OR for obesity was lower among participants with 1 sibling (OR 0.72, 95% CI 0.54-0.95) and more than 1 sibling (OR 0.75, 95% CI 0.56-1.01) compared with those with no siblings.
Children without siblings had poorer cardiovascular risk factor levels in childhood and in adulthood. The number of siblings could help identify individuals at increased risk that might benefit from early intervention.
确定兄弟姐妹数量与儿童和成年期心血管危险因素的关联。
共有 3554 名参与者（51%为女性）参加了心血管风险在芬兰年轻人研究，他们在基线时有心血管疾病风险因素数据（年龄 3-18 岁），2491 名参与者在 2011 年随访时有纵向风险因素数据。参与者按基线时的兄弟姐妹数量分类（0、1 或 1 个以上）。将儿童期和成年期的风险因素（体重指数、身体活动、高血压、血脂异常、超重和代谢综合征）作为结局。分析调整了年龄和性别因素。
在儿童期，无兄弟姐妹的参与者体重指数较高（18.2kg/m，95%置信区间 18.0-18.3），而有 1 个兄弟姐妹（17.9kg/m，95%置信区间 17.8-18.0）或 1 个以上兄弟姐妹（17.8kg/m，95%置信区间 17.7-17.9）的参与者体重指数较低。无兄弟姐妹的儿童期体力活动指数较低（SD-0.08，95%置信区间-0.16 至 0.00），而有 1 个兄弟姐妹（SD 0.06，95%置信区间 0.01 至 0.11）或 1 个以上兄弟姐妹（SD-0.02，95%置信区间-0.07 至 0.03）的参与者体力活动指数较高。与无兄弟姐妹的参与者相比，有 1 个兄弟姐妹（OR 0.73，95%置信区间 0.54-0.98）和 1 个以上兄弟姐妹（OR 0.71，95%置信区间 0.52-0.97）的参与者成年期高血压的比值比（OR）较低。与无兄弟姐妹的参与者相比，有 1 个兄弟姐妹（OR 0.72，95%置信区间 0.54-0.95）和 1 个以上兄弟姐妹（OR 0.75，95%置信区间 0.56-1.01）的参与者肥胖的比值比（OR）较低。
无兄弟姐妹的儿童在儿童期和成年期的心血管风险因素水平较差。兄弟姐妹的数量可以帮助识别处于高风险的个体，这些个体可能受益于早期干预。
