Laboratory of Stem Cell Biology and Molecular Embryology, The Rockefeller University, New York, NY, USA.
Laboratory of Stem Cell Biology and Molecular Embryology, The Rockefeller University, New York, NY, USA.
Cell Stem Cell. 2021 Jun 3;28(6):985-987. doi: 10.1016/j.stem.2021.05.010.
Recent advances in human naive pluripotent stem cell culture have demonstrated their ability to generate trophectoderm and descendant trophoblast cell types. Moreover, the same cells when cultured in three-dimensional configurations self-organize to generate blastocyst-like structures called blastoids. These discoveries represent a major step forward in modeling early human embryonic development.
近年来，人类原始多能干细胞培养的进展表明，它们能够生成滋养外胚层和其后代滋养层细胞类型。此外，当这些细胞在三维环境中培养时，它们会自我组织形成类似囊胚的结构，称为类囊胚。这些发现代表着在模拟早期人类胚胎发育方面迈出了重要的一步。
