Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Cell Stem Cell. 2021 Jun 3;28(6):989-990. doi: 10.1016/j.stem.2021.05.005.
Specific cell targeting with one site-specific recombinase is challenging. In this issue of Cell Stem Cell, Han et al. (2021) released a collection of Dre drivers and demonstrate how two recombinases can be combined to improve the cell specificity of lineage tracing and gene inactivation in mice.
利用单一的位点特异性重组酶进行特定细胞靶向是具有挑战性的。在本期《细胞干细胞》中，Han 等人（2021）发布了一系列 Dre 驱动子，并展示了如何将两种重组酶组合使用，以提高小鼠谱系示踪和基因敲除的细胞特异性。
