Department of Genetics, Cell and Developmental Biology, University of Minnesota, Minneapolis, MN 55455, USA.
Department of Genetics, Cell and Developmental Biology, University of Minnesota, Minneapolis, MN 55455, USA.
Structure. 2021 Jun 3;29(6):509-511. doi: 10.1016/j.str.2021.05.008.
Dynamic nuclear positioning requires the formation of robust connections between the cytoskeleton and components of the LINC complex, a protein assembly that spans the nuclear envelope. A new study by Lim et al. (2021) reveals the mechanism of association between the LINC complex proteins Nesprin-1/2 Giant and the cytoplasmic formin FHOD1.
动态核定位需要细胞骨架与核膜连接复合物（LINC complex）成分之间形成牢固的连接，该复合物由跨越核膜的蛋白质组装而成。Lim 等人的一项新研究揭示了 LINC 复合物蛋白 Nesprin-1/2 Giant 与细胞质formin FHOD1 之间的关联机制。
