核质间的连接体（LINC）形成。
A LINC between the nucleus and the cytoskeleton takes form(in).
机构信息
Department of Genetics, Cell and Developmental Biology, University of Minnesota, Minneapolis, MN 55455, USA.
Department of Genetics, Cell and Developmental Biology, University of Minnesota, Minneapolis, MN 55455, USA.
出版信息
Structure. 2021 Jun 3;29(6):509-511. doi: 10.1016/j.str.2021.05.008.
Abstract
Dynamic nuclear positioning requires the formation of robust connections between the cytoskeleton and components of the LINC complex, a protein assembly that spans the nuclear envelope. A new study by Lim et al. (2021) reveals the mechanism of association between the LINC complex proteins Nesprin-1/2 Giant and the cytoplasmic formin FHOD1.
摘要
动态核定位需要细胞骨架与核膜连接复合物（LINC complex）成分之间形成牢固的连接，该复合物由跨越核膜的蛋白质组装而成。Lim 等人的一项新研究揭示了 LINC 复合物蛋白 Nesprin-1/2 Giant 与细胞质formin FHOD1 之间的关联机制。
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本文引用的文献
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Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins.FHOD1-Nesprin1/2 复合物的结构揭示了formin 的 FH3 结构域的交替结合模式。
Structure. 2021 Jun 3;29(6):540-552.e5. doi: 10.1016/j.str.2020.12.013. Epub 2021 Jan 19.
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ERK1/2 Phosphorylation of FHOD Connects Signaling and Nuclear Positioning Alternations in Cardiac Laminopathy.ERK1/2 磷酸化 FHOD 将心脏层粘连蛋白病中的信号转导和核定位改变联系起来。
Dev Cell. 2019 Dec 2;51(5):602-616.e12. doi: 10.1016/j.devcel.2019.10.023.
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and human FHOD family formin proteins nucleate actin filaments.并且人类 FHOD 家族形成蛋白成核肌动蛋白丝。
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Probing the origins of metazoan formin diversity: Evidence for evolutionary relationships between metazoan and non-metazoan formin subtypes.探究后生动物formin多样性的起源：后生动物与非后生动物formin亚型之间进化关系的证据。
PLoS One. 2017 Oct 5;12(10):e0186081. doi: 10.1371/journal.pone.0186081. eCollection 2017.
5
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Nat Cell Biol. 2014 Jul;16(7):708-15. doi: 10.1038/ncb2981. Epub 2014 Jun 1.
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Cell. 2013 Mar 14;152(6):1376-89. doi: 10.1016/j.cell.2013.02.031.
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