从柳叶菜内生真菌塔宾曲霉中分离得到的一种诺波甾烷和阿糖醇苯甲酸酯。
A norbisabolane and an arabitol benzoate from Talaromyces marneffei, an endophytic fungus of Epilobium angustifolium.
机构信息
School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050,PR China; The Provincial Education Key Laboratory of Screening, Evaluation and Advanced Processing of Traditional Chinese Medicine and Tibetan Medicine, School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, PR China.
School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050,PR China; The Provincial Education Key Laboratory of Screening, Evaluation and Advanced Processing of Traditional Chinese Medicine and Tibetan Medicine, School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, PR China.
出版信息
Fitoterapia. 2021 Sep;153:104948. doi: 10.1016/j.fitote.2021.104948. Epub 2021 Jun 1.
A norbisabolane and an arabitol benzoate, Talaromarnine A (1), Talaromarnine B (2), together with eight known compounds were obtained from cultures of Talaromyces marneffei, an endophytic fungus of Epilobium angustifolium. Their structures were elucidated by IR, MS, 1D and 2D NMR spectra, and their absolute configuration was determined by single-crystal X-ray diffraction and molecular computation. These compounds were tested for monoamine oxidase, acetylcholinesterase and PI3K inhibitory activity, but no compounds exhibited significant activities.
从柳叶菜内生真菌塔宾曲霉菌的发酵液中分离得到一个新的 norbisabolane 倍半萜和一个 arabitol 苯甲酸酯化合物，塔马林胺 A（1）和塔马林胺 B（2），此外还分离得到 8 个已知化合物。通过 IR、MS、1D 和 2D NMR 光谱等方法解析了它们的结构，并通过单晶 X 射线衍射和分子计算确定了它们的绝对构型。对这些化合物进行了单胺氧化酶、乙酰胆碱酯酶和 PI3K 抑制活性测试，但没有化合物表现出显著的活性。
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