School of Life Science and Engineering, Lanzhou University of Technology , Lanzhou , PR China.
Department of Chemistry, Lanzhou University , Lanzhou , PR China.
Nat Prod Res. 2020 Oct;34(19):2802-2808. doi: 10.1080/14786419.2019.1593163. Epub 2019 Mar 31.
Two new compounds Talaromycin A () and Talaromycin B () were isolated from a liquid culture of The structures of and were elucidated by IR, MS, 1D and 2D NMR spectra and comparison of the experimental and calculated electronic circular dichroism spectra. Additional known compounds () were also isolated. These compounds were tested for monoamine oxidase, acetylcholinesterase and PI3K inhibitory activity, but showed only weak activity.
从液体培养的中分离得到了两种新的化合物 Talaromycin A () 和 Talaromycin B ()。通过 IR、MS、1D 和 2D NMR 光谱以及实验和计算电子圆二色谱光谱的比较，确定了 和 的结构。还分离得到了其他已知化合物 ()。这些化合物进行了单胺氧化酶、乙酰胆碱酯酶和 PI3K 抑制活性测试，但仅显示出微弱的活性。
