Lerner S P, Anderson C P, Walford R L, Finch C E
Department of Neurobiology/Gerontology, University of Southern California, Los Angeles 90089-0191.
Biol Reprod. 1988 Jun;38(5):1035-43. doi: 10.1095/biolreprod38.5.1035.
The H-2 (major histocompatibility) complex of mice influences a variety of physiologic parameters. This study describes the influences of H-2 polymorphisms and other genetic influences on age-related changes (5-20 mo) in estrous cycles and fecundity. We monitored estrous cycles of virgin or retired-breeder mice of congenic strains on the background of C57BL/10Sn (B10):B10.BR/Sg (B10.BR) and B10.RIII/Sn (B10.RIII). For another comparison, we examined the C57BL/6J (B6) strain, which has the same H-2 haplotype as the B10. Estrous cycles were categorized by length during 10 mo of observations. From 5 to 15 mo of age, B10 and B10.RIII mice displayed a preponderance of 5-day cycles, B10.BR mice displayed a preponderance of 4-day cycles, and B6 mice had diminishing numbers of 4-day cycles. Age-related acyclicity differed with strain, particularly among retired breeders; B6 mice had an earlier onset and more rapid increase of acyclicity with age than the B10 congenic mice. Litters/female, maternal age at last litter, and total pups/female differed with strain; B10.BR and B10.RIII were similar and both had greater values than B10 mice. In conclusion, reproductive senescence of female mice was influenced by genes at the H-2 locus and elsewhere.
小鼠的H-2（主要组织相容性）复合体影响多种生理参数。本研究描述了H-2多态性和其他遗传因素对动情周期和繁殖力的年龄相关变化（5 - 20个月）的影响。我们监测了C57BL/10Sn（B10）背景下同源近交系处女或经产小鼠的动情周期：B10.BR/Sg（B10.BR）和B10.RIII/Sn（B10.RIII）。为了进行另一项比较，我们检测了C57BL/6J（B6）品系，其与B10具有相同的H-2单倍型。在10个月的观察期内，根据动情周期长度对其进行分类。在5至15月龄时，B10和B10.RIII小鼠以5天周期为主，B10.BR小鼠以4天周期为主，而B6小鼠的4天周期数量逐渐减少。与年龄相关的无动情周期现象因品系而异，尤其是在经产小鼠中；B6小鼠比B10同源近交系小鼠无动情周期现象的发病更早且随年龄增长增加更快。每只雌鼠产仔窝数、最后一窝的母鼠年龄以及每只雌鼠的总仔鼠数因品系而异；B10.BR和B10.RIII相似，且两者的值均高于B10小鼠。总之，雌性小鼠的生殖衰老受H-2位点及其他位点的基因影响。
