Devsthali Vidyapeeth College of Pharmacy, Rudrapur, Uttarakhand, India.
Gurugram University, Gurugram, Haryana, India.
J Cosmet Dermatol. 2022 Aug;21(8):3578-3585. doi: 10.1111/jocd.14674. Epub 2021 Dec 27.
Electromagnetic spectrum of the UV region predominantly becomes the reason for skin's detrimental effects that give the genesis of innumerable skin ailments; because of this reason, the sunscreen products are required before condition in day to day lifestyle; products such as moisturizers, lotions, creams, shampoos, and other hair and skin preparations are accessible and accompanied by sunscreen properties, but they do not provide extended effect, also causes side effects due to harsh chemicals.
The present study focuses on the effects of polyherbal extracts containing Microsponge gel for the protection of skin from ultraviolet rays.
In the present research, already prepared Microsponge gel through quasi-emulsion solvent diffusion (QESD) technique was used for the HPLC, in-silico, in-vitro antioxidant activity, and in-vivo study. AdmetSAR software tool was utilized for the in-silico study, whereas for the in-vivo study, UV radiations are given on Albino rats using solarimeter.
Results shown the active constituents are non-carcinogenic and non-toxic; IC50 values show good antioxidant activity and minimal effect of UV radiations after application of the gel formulation on animal skin.
The results manifest prominent effects on animal skin further test for presence of ascorbic acid level and total protein in blood further verify the efficacy of the formulation.
The study consequently established a strong ground for further extensive clinical studies.
紫外线区域的电磁光谱主要是导致皮肤产生有害影响的原因，从而引发无数皮肤疾病；出于这个原因，在日常生活方式中需要在出门前使用防晒霜产品；保湿霜、乳液、乳膏、洗发水和其他头发和皮肤制剂都具有防晒功能，但它们不能提供持久的效果，而且由于化学物质的苛刻性质，还会引起副作用。
本研究专注于含有 Microsponge 凝胶的草药提取物对皮肤免受紫外线伤害的影响。
在本研究中，通过准乳化溶剂扩散（QESD）技术已经制备了 Microsponge 凝胶，用于 HPLC、计算机模拟、体外抗氧化活性和体内研究。使用 AdmetSAR 软件工具进行计算机模拟研究，而对于体内研究，使用日光计在白化大鼠上给予紫外线辐射。
结果表明，活性成分是非致癌和无毒的；IC50 值表明，在动物皮肤上应用凝胶制剂后具有良好的抗氧化活性和最小的紫外线辐射影响。
结果表明对动物皮肤有显著影响，进一步测试血液中抗坏血酸水平和总蛋白含量进一步验证了配方的功效。
该研究为进一步进行广泛的临床研究奠定了坚实的基础。
