Spilezewski K L, Anderson J M, Schaap R N, Solomon D D
Department of Macromolecular Science, Case Western Reserve University, Cleveland, OH 44106.
Biomaterials. 1988 May;9(3):253-6. doi: 10.1016/0142-9612(88)90093-2.
The inflammatory response to four different catheter materials was quantitatively characterized using an in vivo cage implant system over a 21 d implantation period. The greatest differences between materials were observed at day 4, where the total leucocyte concentration in the exudate decreased in the following order: AE-PVC greater than A-PU greater than D-PU1 greater than D-PU2. Similar trends were observed for the polymorphonuclear leucocyte (PMN) and macrophage concentrations at day 4. At day 7, this trend continued, but by day 21 the total leucocyte concentration, PMN concentration and macrophage concentration had decreased to comparable values for all materials. The extracellular alkaline phosphatase activity at day 4 was lowest for the AE-PVC exudate samples. Similar results were observed for the extracellular acid phosphatase activity but after that time point no significant differences were observed. From these results, it appears that AE-PVC is least biocompatible compared with the other three catheter materials, which were polyurethanes.
使用体内笼式植入系统在21天的植入期内对四种不同导管材料的炎症反应进行了定量表征。材料之间的最大差异在第4天观察到，此时渗出液中的总白细胞浓度按以下顺序降低：AE-PVC大于A-PU大于D-PU1大于D-PU2。在第4天，多形核白细胞（PMN）和巨噬细胞浓度也观察到类似趋势。在第7天，这种趋势持续，但到第21天，所有材料的总白细胞浓度、PMN浓度和巨噬细胞浓度已降至相当的值。第4天，AE-PVC渗出液样品的细胞外碱性磷酸酶活性最低。细胞外酸性磷酸酶活性也观察到类似结果，但在该时间点之后未观察到显著差异。从这些结果来看，与其他三种聚氨酯导管材料相比，AE-PVC的生物相容性似乎最差。
