聚（甲基丙烯酸2-羟乙酯）凝胶衍生残余产物的刺激作用。I. 一些模型化合物的测试。

Irritation effects of residual products derived from poly(2-hydroxyethyl methacrylate) gels. I. Testing of some model compounds.

作者信息

Stol M, Cífková I, Brynda E

机构信息

Research Institute for Rheumatic Diseases, Prague, Czechoslovakia.

出版信息

Biomaterials. 1988 May;9(3):273-6. doi: 10.1016/0142-9612(88)90097-x.

DOI:10.1016/0142-9612(88)90097-x

PMID:3408801

Abstract

2-Hydroxyethyl methacrylate (HEMA) monomer and sodium benzoate, diluted with saline in the range 0-20%, were tested for intradermal irritation in rats. Radioactive indicator (113mIn) was used to quantify this biological response. At low concentrations (up to 1%) only a little irritation was recorded, while at higher levels (5% or more) a significant adverse reaction developed. The degree of irritation was dose dependent. In the concentration range 0-10%, the response was exponential. Model decomposition products derived from three different polymerization initiators were also tested. How the results obtained with the model irritants relate to real polymerization systems is discussed.

摘要

用生理盐水将甲基丙烯酸2-羟乙酯（HEMA）单体和苯甲酸钠稀释至0-20%的范围，对大鼠进行皮内刺激试验。使用放射性指示剂（113mIn）对这种生物学反应进行量化。在低浓度（高达1%）时，仅记录到轻微刺激，而在较高浓度（5%或更高）时，则出现明显的不良反应。刺激程度呈剂量依赖性。在0-10%的浓度范围内，反应呈指数关系。还测试了源自三种不同聚合引发剂的模型分解产物。讨论了模型刺激物所获得的结果与实际聚合体系的关系。