Cífková I, Brynda E, Mandys V, Stol M
State Institute for Drug Control, Prague, Czechoslovakia.
Biomaterials. 1988 Jul;9(4):372-5. doi: 10.1016/0142-9612(88)90036-1.
Samples of poly(2-hydroxyethyl methacrylate) p(HEMA) hydrogels were prepared using three different polymerization initiators. The gels were washed in water under standard conditions. The extracts were then examined for intradermal irritation in rats using a radioactive indicator (113mIn). The irritation effects were dependent on the concentrations of the irritating substances and also on the gel type. Solid discs made of the gels, washed to varying degrees of purity, were also implanted into rats. Tissue irritation, as well as some other biological responses, were followed in situ using the radioindicator and common histological techniques. The irritation effects were very mild (even with the unextracted gel material). A possible explanation for the events taking place at the site of implantation is presented.
使用三种不同的聚合引发剂制备了聚甲基丙烯酸2-羟乙酯（p(HEMA)）水凝胶样品。在标准条件下将凝胶在水中洗涤。然后使用放射性指示剂（113mIn）检查提取物对大鼠的皮内刺激性。刺激效果取决于刺激性物质的浓度以及凝胶类型。由凝胶制成的、洗涤至不同纯度程度的固体圆盘也被植入大鼠体内。使用放射性指示剂和常规组织学技术在原位跟踪组织刺激以及一些其他生物学反应。刺激效果非常轻微（即使是未提取的凝胶材料）。本文提出了植入部位发生的事件的一种可能解释。
