Brynda E, Stol M, Chytrý V, Cífková I
J Biomed Mater Res. 1985 Nov-Dec;19(9):1169-79. doi: 10.1002/jbm.820190923.
Poly(2-hydroxyethyl methacrylate) gels obtained by the cross-linking polymerization using four different free-radical initiators were washed with water. Chromatographically, the eluate appeared to be a mixture of low-molecular-weight compounds and of a small amount of the high-molecular-weight component. The UV and IR absorption spectra of compounds present in the eluate were compared with those of model compounds that were assumed to exist in the gel as impurities after the polymerization (monomers and oligomers of hydroxyethyl methacrylate, decomposition products of initiators). Time dependences of the removal of impurities from the gels by washing were measured. Most of the impurities were washed out within a few hours. In addition to the assumed impurities, the eluate was found to contain an unidentified compound that was still washed out after several months. Intracutaneous applications of this compound did not produce local irritation of the tested tissue.
使用四种不同自由基引发剂通过交联聚合得到的聚甲基丙烯酸2-羟乙酯凝胶用水洗涤。从色谱分析来看，洗脱液似乎是低分子量化合物和少量高分子量组分的混合物。将洗脱液中存在的化合物的紫外和红外吸收光谱与聚合后假定作为凝胶中杂质存在的模型化合物（甲基丙烯酸2-羟乙酯的单体和低聚物、引发剂的分解产物）的光谱进行比较。测定了通过洗涤从凝胶中去除杂质的时间依赖性。大多数杂质在几小时内被洗出。除了假定的杂质外，还发现洗脱液中含有一种未鉴定的化合物，即使在几个月后仍被洗出。该化合物的皮内应用未对受试组织产生局部刺激。
