Teodorczyk-Injeyan J A, Kellen J A
Department of Surgery, University of Toronto, Ontario, Canada.
Biomed Pharmacother. 1988;42(1):49-53.
Some fetal and placental proteins may play a role in stimulating normal and malignant cell proliferation. We studied the effect of human chorionic gonadotropin (hCG) on the proliferative response of mitogen or alloantigen-activated, human peripheral blood mononuclear cells (PBM). The effect of hCG on polyclonal immunoglobulin synthesis was determined in pokeweed mitogen-activated cultures of PBM. hCG had a statistically discernible, augmenting effect on thymidine uptake in lectin-stimulated mononuclear cell cultures. This effect appeared to be dose-dependent, with an optimal range at 50-150 ng/hCG/ml. Polyclonal IgG and IgM synthesis was also significantly increased, both in PWM-stimulated and PWM-free cultures of PBM. Parallel studies with a rapidly growing EB-virus transformed lymphoblastoid line showed no hCG effect. In contrast to previous reports on the immunosuppressive action of hCG, we conclude that hCG functions, in our experimental conditions, as a mitogen and a stimulator of polyclonal immunoglobulin synthesis.
一些胎儿和胎盘蛋白可能在刺激正常细胞和恶性细胞增殖中发挥作用。我们研究了人绒毛膜促性腺激素（hCG）对有丝分裂原或同种异体抗原激活的人外周血单个核细胞（PBM）增殖反应的影响。在商陆有丝分裂原激活的PBM培养物中测定了hCG对多克隆免疫球蛋白合成的影响。hCG对凝集素刺激的单核细胞培养物中的胸腺嘧啶核苷摄取具有统计学上可辨别的增强作用。这种作用似乎呈剂量依赖性，最佳范围为50 - 150 ng/hCG/ml。在PBM的PWM刺激和无PWM培养物中，多克隆IgG和IgM合成也显著增加。对快速生长的EB病毒转化的淋巴母细胞系的平行研究显示hCG无作用。与先前关于hCG免疫抑制作用的报道相反，我们得出结论，在我们的实验条件下，hCG作为一种有丝分裂原和多克隆免疫球蛋白合成的刺激剂发挥作用。
