Otmani Naïma, Hattad Siham
Pediatric Hematology and Oncology Unit, Children Hospital's, Rabat, Morocco.
Pediatric Hematology and Oncology Unit, Children Hospital's, Rabat, Morocco.
Semin Oncol Nurs. 2021 Jun;37(3):151160. doi: 10.1016/j.soncn.2021.151160. Epub 2021 Jun 1.
This study was conducted to assess the impact of oral mucositis on nutrition and performance status in pediatric cancer patients treated by chemotherapy.
A total of 46 children were followed for mucositis episode, and their mean Oral Assessment Guide score was 20.2. Main concomitant disorders were hematological changes (86.9%), loss of appetite (60.7%), vomiting (28.3%), and diarrhea (10.9%).
Anthropometric changes were highlighted by a decrease in body mass index (P = .03) and a decrease of Waterlow score (P = .007). Most patients had a low Lansky Play Performance Scale (LPPS) ≤40 (86.9%). High mucositis grades (P = .007) and long hospital stay (P = .005) were associated with a significant reduction in Lansky Play Performance Scale. Patient's follow-up showed need for hospitalization (84.8%), delay in chemotherapy treatment (71.7%), use of opioides (34.8%), and use of parenteral nutrition (26.1%). Death occurred in 10.9% of the cases.
These findings illustrate the impact of mucositis on nutrition and performance status in children undergoing chemotherapy, which considerable affected their outcome.
本研究旨在评估口腔黏膜炎对接受化疗的儿科癌症患者营养状况和体能状态的影响。
共对46名儿童的黏膜炎发作情况进行了随访，他们的口腔评估指南平均得分为20.2。主要伴随疾病有血液学改变（86.9%）、食欲不振（60.7%）、呕吐（28.3%）和腹泻（10.9%）。
人体测量学变化表现为体重指数下降（P = 0.03）和沃特洛评分降低（P = 0.007）。大多数患者的兰斯基游戏表现量表（LPPS）得分较低≤40（86.9%）。黏膜炎高分级（P = 0.007）和住院时间长（P = 0.005）与兰斯基游戏表现量表显著降低相关。对患者的随访显示需要住院治疗（84.8%）、化疗延迟（71.7%）、使用阿片类药物（34.8%）和使用肠外营养（26.1%）。10.9%的病例发生死亡。
这些发现说明了黏膜炎对接受化疗儿童的营养状况和体能状态的影响，这对他们的预后有相当大的影响。
