Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT, USA.
Pacific Biosciences Research Center, Kewalo Marine Laboratory, University of Hawai'i at Mānoa, Honolulu, HI, USA.
Nat Rev Microbiol. 2021 Oct;19(10):666-679. doi: 10.1038/s41579-021-00567-y. Epub 2021 Jun 4.
For more than 30 years, the association between the Hawaiian bobtail squid, Euprymna scolopes, and the bioluminescent bacterium Vibrio fischeri has been studied as a model system for understanding the colonization of animal epithelia by symbiotic bacteria. The squid-vibrio light-organ system provides the exquisite resolution only possible with the study of a binary partnership. The impact of this relationship on the partners' biology has been broadly characterized, including their ecology and evolutionary biology as well as the underlying molecular mechanisms of symbiotic dynamics. Much has been learned about the factors that foster initial light-organ colonization, and more recently about the maturation and long-term maintenance of the association. This Review synthesizes the results of recent research on the light-organ association and also describes the development of new horizons for E. scolopes as a model organism that promises to inform biology and biomedicine about the basic nature of host-microorganism interactions.
三十多年来，夏威夷短尾乌贼（Euprymna scolopes）与发光细菌费氏弧菌（Vibrio fischeri）之间的共生关系一直被作为研究动物上皮细胞被共生细菌定殖的模型系统。鱿鱼-弧菌发光器官系统提供了只有通过研究二元伙伴关系才能实现的精确分辨率。这种关系对伙伴生物的影响已经得到了广泛的描述，包括它们的生态学和进化生物学以及共生动力学的基础分子机制。人们已经了解了促进最初发光器官定殖的因素，最近还了解了该共生体的成熟和长期维持的相关因素。本综述综合了最近关于发光器官共生关系的研究结果，还描述了将夏威夷短尾乌贼开发为模型生物的新领域，有望为生物学和生物医学提供有关宿主-微生物相互作用的基本性质的信息。
